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A genomewide admixture map for Latino populations

  1. Author:
    Price, A. L.
    Patterson, N.
    Yu, F.
    Cox, D. R.
    Waliszewska, A.
    McDonald, G. J.
    Tandon, A.
    Schirmer, C.
    Neubauer, J.
    Bedoya, G.
    Duque, C.
    Villegas, A.
    Bortolini, M. C.
    Salzano, F. M.
    Gallo, C.
    Mazzotti, G.
    Tello-Ruiz, M.
    Riba, L.
    Aguilar-Salinas, C. A.
    Canizales-Quinteros, S.
    Menjivar, M.
    Klitz, W.
    Henderson, B.
    Haiman, C. A.
    Winkler, C.
    Tusie-Luna, T.
    Ruiz-Linares, A.
    Reich, D.

  2. Author Address

    Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. MIT, Broad Inst, Med & Populat Genet Grp, Cambridge, MA 02139 USA. Perlegen Sci, Mountain View, CA USA. Univ Antioquia, Genet Mol Lab, Medellin, Colombia. Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS, Brazil. Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Labs Invest & Desarrollo, Lima, Peru. Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA. Univ Nacl Autonoma Mexico, Unit Mol Biol & Genom Med, Inst Invest Biomed, Mexico City 04510, DF, Mexico. Univ Nacl Autonoma Mexico, Dept Biol, Fac Quim, Mexico City 04510, DF, Mexico. Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Mexico City, DF, Mexico. Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. Inst Publ Hlth, Oakland, CA USA. Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA. NCI, SAIC Frederick, Lab Genom Divers, Frederick, MD 21701 USA. UCL, Dept Biol, Galton Lab, London, England.;Reich, D, Harvard Univ, Sch Med, Dept Genet, 77 Ave Louis Pasteur, Boston, MA 02115 USA.;reich@genetics.med.harvard.edu
    1. Year: 2007
    2. Date: Jun
  2. Journal: American Journal of Human Genetics
    1. 80
    2. 6
    3. Pages: 1024-1036
  4. Type of Article: Article
  5. ISSN: 0002-9297
  1. Abstract:

    Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise for Latinos, who typically inherit a mix of European, Native American, and African ancestry. However, admixture mapping in Latinos has not been practical because of the lack of a map of ancestry-informative markers validated in Native American and other populations. To address this, we screened multiple databases, containing millions of markers, to identify 4,186 markers that were putatively informative for determining the ancestry of chromosomal segments in Latino populations. We experimentally validated each of these markers in at least 232 new Latino, European, Native American, and African samples, and we selected a subset of 1,649 markers to form an admixture map. An advantage of our strategy is that we focused our map on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. We evaluated the effectiveness of our map for localizing disease genes in four Latino populations from both North and South America.

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External Sources

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  2. DOI: 10.1086/518313
  3. View record in Web of Science®
  4. WOS: 000246553800003

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