Skip NavigationSkip to Content
Return Return to Search Results

Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses

  1. Author:
    Ahlenstiel, G.
    Martin, M. P.
    Gao, X. J.
    Carrington, M.
    Rehermann, B.

  2. Author Address

    Ahlenstiel, Golo, Rehermann, Barbara] NIDDK, Immunol Sect, Liver Dis Branch, NIH,DHHS, Bethesda, MD 20892 USA. [Martin, Maureen P.; Gao, Xiaojiang, Carrington, Mary] Sci Applicat Int Corp Frederick Inc, Natl Canc Inst Frederick, Lab Genom Divers, Frederick, MD USA.
    1. Year: 2008
  2. Journal: Journal of Clinical Investigation
    1. 118
    2. 3
    3. Pages: 1017-1026
  4. Type of Article: Article
  1. Abstract:

    Genetic studies suggest a role for killer cell immunoglobulin-like receptor/HLA (KIR/HLA) compound genotypes in the outcome of viral infections, but functional data to explain these epidemiological observations have not been reported. Using an in vitro model of infection with influenza A virus (IAV), we attribute functional differences in human NK cell activity to distinct KIR/HLA genotypes. Multicolor flow cytometry revealed that the HLA-C-inhibited NK cell subset in HLA-C1 homozygous subjects was larger and responded more rapidly in IFN-gamma secretion and CD107a degranulation assays than its counterpart in HLA-C2 homozygous subjects. The differential IFN-gamma response was also observed at the level of bulk NK cells and was independent of KIR3DL1/HLA-Bw4 interactions. Moreover, the differential response was not caused by differences in NK cell maturation status and phenotype, nor by differences in the type IIFN response of IAV-infected accessory cells between HLA-C1 and HLA-C2 homozygous subjects. These results provide functional evidence for differential NK cell responsiveness depending on KIR/HLA genotype and may provide useful insights into differential innate immune responsiveness to viral infections such as IAV.

    See More

  1. Keywords:

External Sources

  1. PMID: 18246204

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel