Skip NavigationSkip to Content
Return Return to Search Results

HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells

  1. Author:
    Catalfamo, M.
    Di Mascio, M.
    Hu, Z.
    Srinivasula, S.
    Thaker, V.
    Adelsberger, J.
    Rupert, A.
    Baseler, M.
    Tagaya, Y.
    Roby, G.
    Rehm, C.
    Follmann, D.
    Lane, H. C.

  2. Author Address

    Catalfamo, Marta, Thaker, Vishakha, Roby, Gregg, Rehm, Catherine, Lane, H. Clifford] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. [Di Mascio, Michele, Hu, Zonghui, Follmann, Dean] NIAID, Biostat Res Branch, Bethesda, MD 20892 USA. [Adelsberger, Joseph, Rupert, Adam, Baseler, Michael] Sci Applicat Int Corp, AIDS Monitoring Labs, Frederick, MD 21702 USA. [Srinivasula, Sharat] Sci Applicat Int Corp, Biostat Res Branch, Frederick, MD 21702 USA. [Tagaya, Yutaka] NCI, Metab Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
    1. Year: 2008
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 105
    2. 50
    3. Pages: 19851-19856
  4. Type of Article: Article
  1. Abstract:

    HIV infection is characterized by a brisk immune activation that plays an important role in the CD4 depletion and immune dysfunction of patients with AIDS. The mechanism underlying this activation is poorly understood. In the current study, we tested the hypothesis that this activation is the net product of two distinct pathways: the inflammatory response to HIV infection and the homeostatic response to CD4 T cell depletion. Using ex vivo BrdU incorporation of PBMCs from 284 patients with different stages of HIV infection, we found that CD4 proliferation was better predicted by the combination of CD4 depletion and HIV viral load (R-2 = 0.375, P < 0.001) than by either parameter alone (CD4 T cell counts, R-2 = 0.202, P < 0.001, HIV viremia, R-2 = 0.302, P < 0.001). Interestingly, CD8 T cell proliferation could be predicted by HIV RNA levels alone (R-2 = 0.334, P < 0.001) and this predictive value increased only slightly (R-2 = 0.346, P < 0.001) when CD4 T cell depletion was taken into account. Consistent with the hypothesis that CD4 T cell proliferation is driven by IL-7 as a homeostatic response to CD4 T cell depletion, levels of phosphorylated STAT-5 were found to be elevated in naive subsets of CD4 and CD8 T cells from patients with HIV infection and in the central memory subset of CD4 T cells. Taken together these data demonstrate that at least two different pathways lead to immune activation of T cells in patients with HIV infection and these pathways differentially influence CD4 and CD8 T cell subsets.

    See More

  1. Keywords:

External Sources

  1. PMID: 19060209

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel