Skip NavigationSkip to Content
Return Return to Search Results

Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1

  1. Author:
    Mackelprang, R. D.
    John-Stewart, G.
    Carrington, M.
    Richardson, B.
    Rowland-Jones, S.
    Gao, X.
    Mbori-Ngacha, D.
    Mabuka, J.
    Lohman-Payne, B.
    Farquhar, C.

  2. Author Address

    Mackelprang, Romel D.; John-Stewart, Grace, Farquhar, Carey] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA. [John-Stewart, Grace, Lohman-Payne, Barbara, Farquhar, Carey] Univ Washington, Dept Med, Seattle, WA 98104 USA. [Richardson, Barbra] Univ Washington, Dept Biostat, Seattle, WA 98104 USA. [Carrington, Mary, Gao, Xiaojiang] Sci Applicat Int Corp, Lab Genom Divers, Frederick, MD USA. [Carrington, Mary, Gao, Xiaojiang] NCI, Frederick, MD 21701 USA. [Mbori-Ngacha, Dorothy, Mabuka, Jennifer, Lohman-Payne, Barbara] Univ Nairobi, Dept Paediat, Nairobi, Kenya. [Rowland-Jones, Sarah] Weatherall Inst Mol Med, MRC, Human Immunol Unit, Oxford, England.
    1. Year: 2008
  2. Journal: Journal of Infectious Diseases
    1. 197
    2. 8
    3. Pages: 1156-1161
  4. Type of Article: Proceedings Paper
  1. Abstract:

    Background. Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune responses. Methods. We analyzed mother-child HLA concordance and maternal HLA homozygosity in a Kenyan perinatal cohort receiving antenatal zidovudine. HLA concordance was scored as the number of shared class I alleles, and relative risk estimates were adjusted for maternal HIV-1 load. Results. Among 277 mother-infant pairs, HIV-1 transmission occurred in 58 infants (21%), with in utero transmission in 21 (36%), peripartum transmission in 26 (45%), and transmission via breast-feeding in 11 (19%). With increased concordance, we observed a significant increase in the risk of transmission overall (adjusted hazard ratio [aHR], 1.3 [95% confidence interval {CI}, 1.0-1.7]; P = .04), in utero (adjusted odds ratio, 1.72 [95% CI, 1.0-1.7]; P = .04), and via breast-feeding (aHR, 1.6 [95% CI, 1.0-2.5]; P = .04). Women with homozygosity had higher plasma HIV-1 RNA levels at 32 weeks of gestation (5.1 vs. 4.8 log(10) copies/mL, P = .03) and an increased risk of transmission overall (aHR, 1.7 [95% CI, 1.1-2.7]; P = .03) and via breast-feeding (aHR, 5.8 [95% CI, 1.9-17.7]; P = .002). Conclusion. The risks of overall, in utero, and breast milk HIV-1 transmission increased with HLA concordance and homozygosity. The increased risk may be due to reduced alloimmunity or less diverse protective immune responses.

    See More

  1. Keywords:

External Sources

  1. PMID: 18462163

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel