Skip NavigationSkip to Content
Return Return to Search Results

Synthesis of Conformationally Locked Versions of Puromycin Analogues

  1. Author:
    Saneyoshi, H.
    Michel, B. Y.
    Choi, Y.
    Strazewski, P.
    Marquez, V. E.

  2. Author Address

    Saneyoshi, Hisao, Choi, Yongseok, Marquez, Victor E.] NCI, Ctr Canc Res, Med Chem Lab, Frederick, MD 21702 USA. [Michel, Benoit Y.; Strazewski, Peter] Univ Lyon 1, Lab Synth Biomol, Inst Chim & Biochim Mol & Supramol, UMR 5246, F-69622 Villeurbanne, France.
    1. Year: 2008
  2. Journal: Journal of Organic Chemistry
    1. 73
    2. 23
    3. Pages: 9435-9438
  4. Type of Article: Article
  1. Abstract:

    Conformationally locked North and South versions Of puromycin analogues built on a bicyclo[3.1.0]hexane pseudosugar template were synthesized. The final assembly of the products was accomplished by the staudinger-Vilarrasa coupling of the corresponding North (2 and 3) and South (6 and 7) 3'-azidopurine carbanucleosides with the Fmoc-protected 1-hydroxybenzotriazole ester of 4-methoxy-L-tyrosine. North azides 2 and 3 were reported earlier. The 3'-azido intermediates 6 and 7 that are necessary for the synthesis of the South puromycin analogues are described herein for the first time.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel