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The Zinc Finger Transcription Factor Zbtb7b Represses CD8-Lineage Gene Expression in Peripheral CD4(+) T Cells

  1. Author:
    Wang, L.
    Wildt, K. F.
    Castro, E.
    Xiong, Y.
    Feigenbaum, L.
    Tessarollo, L.
    Bosselut, R.

  2. Author Address

    Wang, Lie, Wildt, Kathryn F.; Castro, Ehydel, Xiong, Yumei, Bosselut, Remy] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Feigenbaum, Lionel] NCI SAIC, Frederick, MD 21702 USA. [Tessarollo, Lino] NCI, Mouse Canc Genet Program, CCR, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Immunity
    1. 29
    2. 6
    3. Pages: 876-887 DI 10.1016/j.imm
  4. Type of Article: Article
  1. Abstract:

    How CD4-CD8 differentiation is maintained in mature T cells is largely unknown. The present study has examined the role in this process of the zinc finger protein Zbtb7b, a critical factor for the commitment of MHC II-restricted thymocytes to the CD4(+) lineage. We showed that Zbtb7b acted in peripheral CD4(+) T cells to suppress CD8-lineage gene expression, including that of CD8 and cytotoxic effector genes perforin and Granzyme B, and was important for the proper repression of interferon-gamma (IFN-gamma) during effector differentiation. The inappropriate expression of IFN-gamma by Zbtb7b-deficient CD4(+) T cells required the activities of Eomesodermin and Runx transcription factors. Runx activity was needed for Granzyme B expression, indicating that Runx proteins control expression of the cytotoxic program. We conclude that a key function of Zbtb7b in the mature CD4(+) T cell compartment is to repress CD8-lineage gene expression.

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External Sources

  1. PMID: 19062319

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