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Geographic Variation in the Prevalence of Kaposi Sarcoma-Associated Herpesvirus and Risk Factors for Transmission

  1. Author:
    de Sanjose, S.
    Mbisa, G.
    Perez-Alvarez, S.
    Benavente, Y.
    Sukvirach, S.
    Nguyen, T. H.
    Shin, H. R.
    Pham, T.
    Thomas, J.
    Lazcano, E.
    Matos, E.
    Herrero, R.
    Munoz, N.
    Molano, M.
    Franceschi, S.
    Whitby, D.

  2. Author Address

    de Sanjose, Silvia] Inst Catala Oncol, Unit Infect & Canc, Program Res Canc Epidemiol, IDIBELL,CIBERESP, Barcelona 08907, Spain. [de Sanjose, Silvia, Benavente, Yolanda] Ctr Invest Biomed Red Epidemiol & Salud Publ, Barcelona, Spain. [Sukvirach, Sukhon] Natl Canc Inst, Div Res, Bangkok, Thailand. [Nguyen Trong Hieu, Pham Thi Hoang Anh] Hung Vuong Hosp, Dept Neonatol, Thanh Pho Ho Chi Minh, Vietnam. [Shin, Hai-Rim, Franceschi, Silvia] Int Agcy Res Canc, F-69372 Lyon, France. [Thomas, Jaiyeola] Univ Ibadan, Coll Med, Ibadan, Nigeria. [Lazcano, Eduardo] Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico. [Matos, Elena] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina. [Herrero, Rolando] Fdn Inst Costarricense Invest & Ensenanza Nutr &, San Jose, Costa Rica. [Munoz, Nubia, Molano, Monica] Inst Nacl Cancerol, Bogota, Colombia. [Shin, Hai-Rim] Natl Canc Ctr, Goyang, South Korea. [Mbisa, Georgina, Whitby, Denise] NCI, Viral Oncol Sect, AIDS & Canc Virus Program, Sci Applicat Int Corp Frederick, Frederick, MD 21701 USA.
    1. Year: 2009
  2. Journal: Journal of Infectious Diseases
    1. 199
    2. 10
    3. Pages: 1449-1456
  4. Type of Article: Proceedings Paper
  1. Abstract:

    Background. The aim of the present study was to estimate the prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) in the female general population, to define geographic variation in and heterosexual transmission of the virus. Methods. The study included 10,963 women from 9 countries for whom information on sociodemographic characteristics and reproductive, sexual, and smoking behaviors were available. Antibodies against KSHV that encoded lytic antigen K8.1 and latent antigen ORF73 were determined. Results. The range of prevalence of KSHV (defined as detection of any antigen) was 3.81%-46.02%, with significant geographic variation noted. In Nigeria, the prevalence was 46.02%; in Colombia, 13.32%; in Costa Rica, 9.81%; in Argentina, 6.40%; in Ho Chi Minh City, Vietnam, 15.50%; in Hanoi, Vietnam, 11.26%; in Songkla, Thailand, 10%; in Lampang, Thailand, 8.63%; in Korea, 4.93%; and in Spain, 3.65%. The prevalence of KSHV slightly increased with increasing age among subjects in geographic areas where the prevalence of KSHV was high, such as Nigeria and Colombia, and it significantly decreased with increases in the educational level attained by subjects in those areas. KSHV was not statistically associated with age at first sexual intercourse, number of sex partners, number of children, patterns of oral contraceptive use, presence of cervical human papillomavirus DNA, or smoking status. Conclusions. The study provides comparable estimates of KSHV prevalence in diverse cultural settings across 4 continents and provides evidence that sexual transmission of KSHV is not a major source of infection in the general population.

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  2. DOI: 10.1086/598523
  3. PMID: 19351262

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