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A macaque model of HIV-1 infection

  1. Author:
    Hatziioannou, T.
    Ambrose, Z.
    Chung, N.
    Piatak, M.
    Yuan, F.
    Trubey, C. M.
    Coalter, V.
    Kiser, R.
    Schneider, D.
    Smedley, J.
    Pung, R.
    Gathuka, M.
    Estes, J. D.
    Veazey, R. S.
    KewalRamani, V. N.
    Lifson, J. D.
    Bieniasz, P. D.

  2. Author Address

    Hatziioannou, Theodora, Bieniasz, Paul D.] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10021 USA. [Bieniasz, Paul D.] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA. [Bieniasz, Paul D.] Rockefeller Univ, Lab Retrovirol, New York, NY 10021 USA. [Ambrose, Zandrea, Chung, Nancy P. Y.; KewalRamani, Vineet N.] NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA. [Piatak, Michael, Jr.; Yuan, Fang, Trubey, Charles M.; Coalter, Vicky, Kiser, Rebecca, Schneider, Doug, Estes, Jacob D.; Lifson, Jeffrey D.] NCI, AIDS & Canc Virus Program, Frederick, MD 21702 USA. [Smedley, Jeremy, Pung, Rhonda, Gathuka, Mercy] NCI, Lab Anim Sci Program, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21702 USA. [Veazey, Ronald S.] Tulane Univ, Sch Med, Tulane Natl Primate Res Ctr, Covington, LA 70433 USA.
    1. Year: 2009
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 106
    2. 11
    3. Pages: 4425-4429 DI 10.1073/pnas
  4. Type of Article: Article
  1. Abstract:

    The lack of a primate model that utilizes HIV-1 as the challenge virus is an impediment to AIDS research, existing models generally employ simian viruses that are divergent from HIV-1, reducing their usefulness in preclinical investigations. Based on an understanding of species-specific variation in primate TRIM5 and APOBEC3 antiretroviral genes, we constructed simian-tropic (st) HIV-1 strains that differ from HIV-1 only in the vif gene. We demonstrate that such minimally modified stHIV-1 strains are capable of high levels of replication in vitro in pig-tailed macaque (Macaca nemestrina) lymphocytes. Importantly, infection of pig-tailed macaques with stHIV-1 results in acute viremia, approaching the levels observed in HIV-1-infected humans, and an ensuing persistent infection for several months. stHIV-1 replication was controlled thereafter, at least in part, by CD8+ T cells. We demonstrate the potential utility of this HIV-1-based animal model in a chemoprophylaxis experiment, by showing that a commonly used HIV-1 therapeutic regimen can provide apparently sterilizing protection from infection following a rigorous high-dose stHIV-1 challenge.

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External Sources

  1. PMID: 19255423

Library Notes

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