Skip NavigationSkip to Content
Return Return to Search Results

Human Immunodeficiency Virus and Hepatitis C Infections Induce Distinct Immunologic Imprints in Peripheral Mononuclear Cells

  1. Author:
    Kottilil, S.
    Yan, M. Y.
    Reitano, K. N.
    Zhang, X.
    Lempicki, R.
    Roby, G.
    Daucher, M.
    Yang, J.
    Cortez, K. J.
    Ghany, M.
    Polis, M. A.
    Fauci, A. S.

  2. Author Address

    Kottilil, Shyam] NIAID, Immunopathogenesis Sect, Immunoregulat Lab, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Cortez, Karoll J.] NCI, NIH, DHHS, Bethesda, MD 20892 USA. [Lempicki, Richard, Yang, Jun] SAIC Frederick, Frederick, MD USA. [Cortez, Karoll J.] NIH, Dept Crit Care Med, NIH Clin Ctr, DHHS, Bethesda, MD 20892 USA. [Ghany, Marc] NIDDK, NIH, DHHS, Bethesda, MD USA.
    1. Year: 2009
  2. Journal: Hepatology
    1. 50
    2. 1
    3. Pages: 34-45
  4. Type of Article: Article
  1. Abstract:

    Coinfection with hepatitis C virus (HCV) is present in one-third of all human immunodeficiency virus (HIV)-infected individuals in the United States and is associated with rapid progression of liver fibrosis and poor response to pegylated interferon (IFN) and ribavirin. In this study we examined gene expression profiles in peripheral blood mononuclear cells (PBMCs) from different groups of individuals who are monoinfected or coinfected with HIV and HCV. Data showed that HIV and HCV viremia up-regulate genes associated with immune activation and immunoregulatory pathways. HCV viremia is also associated with abnormalities in all peripheral immune cells, suggesting a global effect of HCV on the immune system. Interferon-alpha-induced genes were expressed at a higher level in PBMCs from HIV-infected individuals. HCV and HIV infections leave distinct profiles or gene expression of immune activation in PBMCs. HIV viremia induces an immune activated state, by comparison, HCV infection induces immunoregulatory and proinflammatory pathways that may contribute to progression of liver fibrosis. Conclusion: An aberrant type-I IFN response seen exclusively in HIV-infected individuals could be responsible for the poor therapeutic response experienced by HIV/HCV coinfected individuals receiving interferon-alpha-based current standard of care. (HEPATOLOGY 2009,50:34-45.)

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1002/hep.23055
  3. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel