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Aryl Hydrocarbon Receptor Expression Is Associated with a Family History of Upper Gastrointestinal Tract Cancer in a High-Risk Population Exposed to Aromatic Hydrocarbons

  1. Author:
    Roth, M. J.
    Wei, W. Q.
    Baer, J.
    Abnet, C. C.
    Wang, G. Q.
    Sternberg, L. R.
    Warner, A. C.
    Johnson, L. L.
    Lu, N.
    Giffen, C. A.
    Dawsey, S. M.
    Qiao, Y. L.
    Cherry, J.

  2. Author Address

    Roth, Mark J.; Abnet, Christian C.; Dawsey, Sanford M.] NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Johnson, Laura Lee] NIH, Natl Ctr Complementary & Alternat Med, Bethesda, MD 20892 USA. [Wei, Wen-Qiang, Qiao, You-Lin] Chinese Acad Med Sci, Dept Canc Epidemiol, Beijing 100037, Peoples R China. [Wang, Guo-Qing] Chinese Acad Med Sci, Dept Endoscopy, Beijing 100037, Peoples R China. [Lu, Ning] Chinese Acad Med Sci, Dept Pathol, Inst Canc, Beijing 100037, Peoples R China. [Baer, Jessica, Cherry, James] Sci Applicat Int Corp Frederick Inc, Natl Canc Inst Frederick, Lab Mol Technol, Frederick, MD USA. [Sternberg, Lawrence R.; Warner, Andrew C.] Sci Applicat Int Corp Frederick Inc, Pathol & Histotechnol Lab, Frederick, MD USA. [Giffen, Carol A.] Informat Management Serv Inc, Silver Spring, MD USA.
    1. Year: 2009
  2. Journal: Cancer Epidemiology Biomarkers & Prevention
    1. 18
    2. 9
    3. Pages: 2391-2396
  4. Type of Article: Article
  1. Abstract:

    Background: Polycyclic aromatic hydrocarbon (PAH) exposure is a risk factor for esophageal squamous cell carcinoma, and PAHs are ligands of the aryl hydrocarbon receptor (AhR). This study measured the expression of AhR and related genes in frozen esophageal cell samples from patients exposed to different levels of indoor air pollution, who did or did not have high-grade squamous dysplasia and who did or did not have a family history of upper gastrointestinal tract (UGI) cancer. Methods: 147 samples were evaluated, including 23 (16%) from patients with high-grade dysplasia and 48 (33%) from patients without dysplasia who heated their homes with coal, without a chimney (a "high" indoor air pollution group), and 27 (18%) from patients with high-grade dysplasia and 49 (33%) from patients without dysplasia who did not heat their homes at all (a "low" indoor air pollution group). Sixty-four (44%) had a family history of UGI cancer. RNA was extracted and quantitative PCR analysis was done. Results: AhR gene expression was detectable in 85 (58%) of the samples and was >9-fold higher in those with a family history of UGI cancer [median expression (interquartile range), -1,964 (-18,000, -610) versus -18,000 (-18,000, -1036); P = 0.02, Wilcoxon rank-sum test]. Heating status, dysplasia category, age, gender, and smoking were not associated with AhR expression (linear regression, all P values >= 0.1). Conclusion: AhR expression was higher in patients with a family history of UGI cancer. Such individuals may be more susceptible to the deleterious effects of PAH exposure, including PAH-induced cancer. (Cancer Epidemiol Biomarkers Prev 2009,18(9):2391-6)

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  2. DOI: 10.1158/1055-9965.epi-08-1098
  3. PMID: 19690180

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