Skip NavigationSkip to Content
Return Return to Search Results

Hemizygosity of the MAX gene locus in HL60 cells

  1. Author:
    Ryan, K. M.
    Al-Mulla, F.
    Jamieson, T.
    Birnie, G. D.

  2. Author Address

    Birnie GD NCI, ABL Basic Res Program, FCRDC Bldg 560,Room 22-45 Frederick, MD 21702 USA Beatson Inst Canc Res, CRC Beatson Labs Glasgow G61 1BD Lanark Scotland
    1. Year: 1998
  2. Journal: Cancer Genetics and Cytogenetics
    1. 107
    2. 2
    3. Pages: 93-97
  4. Type of Article: Article
  1. Abstract:

    The oncogenic activity of c-MYC is well known, and genetic aberrations in this locus are associated with a variety of human neoplasms. Because the encoded MYC protein has transcriptional activity only when dimerized with MAX, it is possible that mutations of MAX also could have phenotypic consequences. We have now found, by fluorescence in situ hybridization and quantified Southern blot analyses, that the MAX gene has been reduced to hemizygosity in HL60 cells. Although the sequence of the coding region of the remaining allele of the MAX gene is not mutated, this reduction in gene dosage may be the cause of a lower abundance of MAX protein in these cells that could result in an imbalance in the complex transcription factor network in which MAX has a pivotal role. (C) Elsevier Science Inc., 1998. [References: 27]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel