Skip NavigationSkip to Content
Return Return to Search Results

Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure

  1. Author:
    Ulrich, N. C.
    Kodet, J. G.
    Mente, N. R.
    Kuder, C. H.
    Beutler, J. A.
    Hohl, R. J.
    Wiemer, D. F.

  2. Author Address

    [Ulrich, Natalie C.; Kodet, John G.; Mente, Nolan R.; Wiemer, David F.] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA. [Kuder, Craig H.; Hohl, Raymond J.; Wiemer, David F.] Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA. [Beutler, John A.] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21701 USA. [Hohl, Raymond J.] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA.;Wiemer, DF, Univ Iowa, Dept Chem, Iowa City, IA 52242 USA.;david-wiemer@uiowa.edu
    1. Year: 2010
    2. Date: Feb
  2. Journal: Bioorganic & Medicinal Chemistry
    1. 18
    2. 4
    3. Pages: 1676-1683
  4. Type of Article: Article
  5. ISSN: 0968-0896
  1. Abstract:

    The natural tetracyclic schweinfurthins are potent and selective inhibitors of cell growth in the National Cancer Institute's 60-cell line screen. An interest in determination of their cellular or molecular target has inspired our efforts to prepare both the natural products and analogues. In this paper, chemical synthesis of analogues modified in different olefinic positions, and preliminary results from studies of their biological activity, are reported. (C) 2010 Elsevier Ltd. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bmc.2009.12.063
  3. View record in Web of Science®
  4. WOS: 000274425500033

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel