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The alarmin functions of high-mobility group proteins

  1. Author:
    Yang, D.
    Tewary, P.
    de la Rosa, G.
    Wei, F.
    Oppenheim, J. J.

  2. Author Address

    [Yang, De; Tewary, Poonam; de la Rosa, Gonzalo; Wei, Feng; Oppenheim, Joost J.] NCI, Mol Immunoregulat Lab, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA. [Yang, De] SAIC Frederick Inc, Basic Sci Program, Frederick, MD 21702 USA.;Oppenheim, JJ, NCI, Mol Immunoregulat Lab, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.;oppenhei@ncifcrf.gov
    1. Year: 2010
    2. Date: Jan-Feb
  2. Journal: Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms
    1. 1799
    2. 1-2
    3. Pages: 157-163
  4. Type of Article: Review
  5. ISSN: 1874-9399
  1. Abstract:

    High-mobility group (HIVIG) proteins are non-histone nuclear proteins that bind nucleosomes and regulate chromosome architecture and gene transcription. Over the past decade, numerous studies have established that some HMG proteins can be released extracellularly and demonstrate distinct extracellular biological activities. Here, we will give a brief overview of HIVIG proteins and highlight their participation in innate/inflammatory and adaptive immune responses. They have the activities of alarmins, which are endogenous mediators that are rapidly released in response to danger signals initiated by infection and/or tissue damage and are capable of activating innate and adaptive immunity by promoting the recruitment and activation of antigen-presenting cells (APCs). (C) 2009 Published by Elsevier B.V.

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External Sources

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  2. DOI: 10.1016/j.bbagrm.2009.11.002
  3. View record in Web of Science®
  4. WOS: 000274868500020

Library Notes

  1. Fiscal Year: FY2009-2010
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