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Macrophages and Cell-Cell Spread of HIV-1

  1. Author:
    Waki, K.
    Freed, E. O.

  2. Author Address

    [Waki, Kayoko; Freed, Eric O.] NCI, Virus Cell Interact Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA.;Freed, EO, NCI, Virus Cell Interact Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA.;wakik@mail.nih.gov efreed@nih.gov
    1. Year: 2010
    2. Date: Aug
  2. Journal: Viruses-Basel
    1. 2
    2. 8
    3. Pages: 1603-1620
  4. Type of Article: Review
  5. ISSN: 1999-4915
  1. Abstract:

    Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/v2081603
  3. View record in Web of Science®
  4. WOS: 000282477000008

Library Notes

  1. Fiscal Year: FY2009-2010
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