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Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial

  1. Author:
    Bobe, G.
    Murphy, G.
    Albert, P. S.
    Sansbury, L. B.
    Lanza, E.
    Schatzkin, A.
    Colburn, N. H.
    Cross, A. J.

  2. Author Address

    [Bobe, G.; Lanza, E.; Colburn, N. H.] NCI, Lab Canc Prevent, Ctr Canc Res, NIH,Dept Hlth & Human Serv, Frederick, MD 21702 USA. [Murphy, G.] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA. [Albert, P. S.] NICHHD, Biostat & Bioinformat Branch, NIH, DHHS, Bethesda, MD 20892 USA. [Sansbury, L. B.] NCI, Epidemiol & Genet Res Program, Div Canc Control & Populat Sci, NIH,DHHS, Bethesda, MD 20892 USA. [Schatzkin, A.; Cross, A. J.] NCI, Nutr Epidemiol Branch, DCEG, NIH,DHHS, Bethesda, MD 20892 USA.;Bobe, G, NCI, Lab Canc Prevent, Ctr Canc Res, NIH,Dept Hlth & Human Serv, Bldg 576,Room 101,1050 Boyles St, Frederick, MD 21702 USA.;gerd.bobe@oregonstate.edu
    1. Year: 2010
    2. Date: Oct
  2. Journal: British Journal of Cancer
    1. 103
    2. 9
    3. Pages: 1453-1461
  4. Type of Article: Article
  5. ISSN: 0007-0920
  1. Abstract:

    BACKGROUND: Serum cytokine concentrations may reflect inflammatory processes occurring during the development of colorectal neoplasms. Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation. METHODS: Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the association between serum concentrations of interleukin (IL) 1 beta, 2, 8, 10, 12p70, granulocyte macrophage colony stimulating factor, interferon-gamma, and tumour necrosis factor-alpha, measured over time, flavonol intake, estimated from a flavonol database used in conjunction with a food frequency questionnaire, and adenoma recurrence in 872 participants from the intervention arm of the Polyp Prevention Trial. RESULTS: Decreased IL-2 concentration during the trial increased the risk of any adenoma recurrence (4th vs 1st quartile, OR = 1.68, 95% CI = 1.13-2.49), whereas decreased IL-1 beta or IL-10 reduced the risk of advanced adenoma recurrence (OR = 0.37, 95% CI = 0.15-0.94; OR = 0.39, 95% CI = 0.15-0.98, respectively). Individuals with flavonol intake above the median (29.7 mg per day) and decreased cytokine concentrations had the lowest risk of advanced adenoma recurrence. CONCLUSION: Overall, no consistent associations were observed between serum cytokine profile and colorectal adenoma recurrence; however, decreased cytokine concentrations during high flavonol consumption may indicate prevention of colorectal neoplasms. British Journal of Cancer (2010) 103, 1453-1461. doi: 10.1038/sj.bjc.6605915 www.bjcancer.com Published online 5 October 2010 (C) 2010 Cancer Research UK

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  2. DOI: 10.1038/sj.bjc.6605915
  3. View record in Web of Science®
  4. WOS: 000283540300020

Library Notes

  1. Fiscal Year: FY2010-2011
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