Skip NavigationSkip to Content

An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke

  1. Author:
    Li, S. L.
    Overman, J. J.
    Katsman, D.
    Kozlov, S. V.
    Donnelly, C. J.
    Twiss, J. L.
    Giger, R. J.
    Coppola, G.
    Geschwind, D. H.
    Carmichael, S. T.
  2. Author Address

    [Li, Songlin; Overman, Justine J.; Katsman, Diana; Coppola, Giovanni; Geschwind, Daniel H.; Carmichael, S. Thomas] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA. [Kozlov, Serguei V.] NCI, Canc & Dev Biol Lab, Frederick, MD 21701 USA. [Donnelly, Christopher J.; Twiss, Jeffery L.] Drexel Univ, Dept Biol, Philadelphia, PA 19104 USA. [Giger, Roman J.] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA. [Giger, Roman J.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.;Carmichael, ST, Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA.;scarmichael@mednet.ucla.edu
    1. Year: 2010
    2. Date: Dec
  1. Journal: Nature Neuroscience
    1. 13
    2. 12
    3. Pages: 1496-U82
  2. Type of Article: Article
  3. ISSN: 1097-6256
  1. Abstract:

    Stroke is an age-related disease. Recovery after stroke is associated with axonal sprouting in cortex adjacent to the infarct. The molecular program that induces a mature cortical neuron to sprout a new connection after stroke is not known. We selectively isolated neurons that sprout a new connection in cortex after stroke and compared their whole-genome expression profile to that of adjacent, non-sprouting neurons. This 'sprouting transcriptome' identified a neuronal growth program that consists of growth factor, cell adhesion, axonal guidance and cytoskeletal modifying molecules that differed by age and time point. Gain and loss of function in three distinct functional classes showed new roles for these proteins in epigenetic regulation of axonal sprouting, growth factor-dependent survival of neurons and, in the aged mouse, paradoxical upregulation of myelin and ephrin receptors in sprouting neurons. This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery.

    See More

External Sources

  1. DOI: 10.1038/nn.2674
  2. WOS: 000284525800014

Library Notes

  1. Fiscal Year: FY2010-2011
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel