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Isolation and Characterization of Minor Analogues of Silvestrol and Other Constituents from a Large-Scale Re-collection of Aglaia foveolata

  1. Author:
    Pan, L.
    Kardono, L. B. S.
    Riswan, S.
    Chai, H.
    de Blanco, E. J. C.
    Pannell, C. M.
    Soejarto, D. D.
    McCloud, T. G.
    Newman, D. J.
    Kinghorn, A. D.

  2. Author Address

    Ohio State Univ, Div Med Chem, Coll Pharm, Columbus, OH 43210 USA. [Kardono, Leonardus B. S.] Indonesian Inst Sci, Res Ctr Chem, Tangerang 15310, Indonesia. [Riswan, Soedarsono] Indonesian Inst Sci, Herbarium Bogoriense, Biol Res Ctr, Bogor 16122, Indonesia. [de Blanco, Esperanza J. Carcache] Ohio State Univ, Coll Pharm, Div Pharm Practice & Adm, Columbus, OH 43210 USA. [Pannell, Caroline M.] Univ Oxford, Dept Plant Sci, Oxford OX1 3RA, England. [Soejarto, Djaja Doel] Univ Illinois, Program Collaborat Res Pharmaceut Sci, Coll Pharm, Chicago, IL 60612 USA. [Soejarto, Djaja Doel] Univ Illinois, Dept Med Chem & Pharmacognosy, Coll Pharm, Chicago, IL 60612 USA. [McCloud, Thomas G.] SAIC Frederick Inc, Frederick, MD 21702 USA. [Newman, David J.] NCI Frederick, Fairview Ctr, Frederick, MD 21702 USA.;Kinghorn, AD, Ohio State Univ, Div Med Chem & Pharmacognosy, Coll Pharm, Columbus, OH 43210 USA.;kinghorn.4@osu.edu
    1. Year: 2010
    2. Date: Nov
  2. Journal: Journal of Natural Products
    1. 73
    2. 11
    3. Pages: 1873-1878
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    Two new minor silvestrol analogues [2 '''-episilvestrol (1) and 2 ''',5 '''-diepisilvestrol (2)], together with a new 21-norbaccharane-type triterpene (3), two new 3,4-secodammarane triterpenes (4 and 5), and a new eudesmane sesquiterpene (6), as well as nine known compounds, were isolated from a large-scale re-collection of the CHCl3-soluble extract of the stem bark of Aglaia foveolata obtained in Kalimantan, Indonesia. The structures of the new compounds were established by interpretation of their spectroscopic data. All of the isolates were tested for cytotoxicity against HT-29 cells. The new silvestrol analogues, 1 and 2, were considerably less active as cytotoxic agents than silvestrol (7) and episilvestrol (5 '''-episilvestrol) (8) against this cell line, showing the importance of the configuration at C-2 ''' in mediating such activity within this compound class. Several of the compounds isolated were also evaluated in a NF-kappa B (p65) inhibition assay.

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External Sources

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  2. DOI: 10.1021/np100503q
  3. View record in Web of Science®
  4. WOS: 000284559100022

Library Notes

  1. Fiscal Year: FY2010-2011
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