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Similarity in Recombination Rate Estimates Highly Correlates with Genetic Differentiation in Humans

  1. Author:
    Laayouni, H. L. H.
    Montanucci, L.
    Sikora, M.
    Mele, M.
    Dall'Olio, G. M.
    Lorente-Galdos, B.
    McGee, K. M.
    Graffelman, J.
    Awadalla, P.
    Bosch, E.
    Comas, D.
    Navarro, A.
    Calafell, F.
    Casals, F.
    Bertranpetit, J.

  2. Author Address

    [Laayouni, H Laayouni, H; Montanucci, L; Sikora, M; Mele, M; Dall'Olio, GM; Lorente-Galdos, B; Bosch, E; Comas, D; Navarro, A; Calafell, F; Casals, F; Bertranpetit, J] CEXS UPF PRBB, Inst Evolutionary Biol UPF CSIC, IBE, Barcelona, Catalonia, Spain [McGee, KM] NCI, NIH, Frederick, MD 21701 USA [Graffelman, J] Univ Politecn Cataluna, Dept Stat & Operat Res, Barcelona, Spain [Awadalla, P; Casals, F] Univ Montreal, Fac Med, Ste Justine Hosp, Res Ctr, Montreal, PQ H3C 3J7, Canada [Navarro, A] Inst Catalana Recerca & Estudis Avancats, Barcelona, Catalonia, Spain [Navarro, A] Natl Inst Bioinformat INB, Barcelona, Spain;Laayouni, H (reprint author), CEXS UPF PRBB, Inst Evolutionary Biol UPF CSIC, IBE, Barcelona, Catalonia, Spain;jaume.bertranpetit@upf.edu
    1. Year: 2011
    2. Date: Mar
  2. Journal: Plos One
    1. 6
    2. 3
    3. Pages: 8
  4. Type of Article: Article
  5. Article Number: e17913
  6. ISSN: 1932-6203
  1. Abstract:

    Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution of recombination. Here, we analyze its recent evolution in humans. We calculated the recombination rates between adjacent pairs of 636,933 common single-nucleotide polymorphism loci in 28 worldwide human populations and analyzed them in relation to genetic distances between populations. We found a strong and highly significant correlation between similarity in the recombination rates corrected for effective population size and genetic differentiation between populations. This correlation is observed at the genome-wide level, but also for each chromosome and when genetic distances and recombination similarities are calculated independently from different parts of the genome. Moreover, and more relevant, this relationship is robustly maintained when considering presence/absence of recombination hotspots. Simulations show that this correlation cannot be explained by biases in the inference of recombination rates caused by haplotype sharing among similar populations. This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans.

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External Sources

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  2. DOI: 10.1371/journal.pone.0017913
  3. View record in Web of Science®
  4. WOS: 000289053800005

Library Notes

  1. Fiscal Year: FY2010-2011
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