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HIV-1 infected monozygotic twins: a tale of two outcomes

  1. Author:
    Tazi, L. T. L.
    Imamichi, H.
    Hirschfeld, S.
    Metcalf, J. A.
    Orsega, S.
    Perez-Losada, M.
    Posada, D.
    Lane, H. C.
    Cr, all

  2. Author Address

    [Tazi, L Tazi, L] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Brownsville, TX USA [Imamichi, H] NCI, Lab Mol Retrovirol, Clin Serv Program, SAIC Frederick Inc, Frederick, MD 21701 USA [Imamichi, H; Lane, HC] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA [Hirschfeld, S] NICHHD, NIH, Bethesda, MD 20892 USA [Metcalf, JA; Orsega, S] NIAID, Collaborat Clin Res Branch, Div Clin Res, NIH, Bethesda, MD 20892 USA [Perez-Losada, M] Univ Porto, CIBIO, Ctr Invest Biodiversidade & Recursos Genet, Vairao, Portugal [Posada, D] Univ Vigo, Dept Biochem Genet & Immunol, Vigo 36310, Spain [Crandall, KA] Brigham Young Univ, Dept Biol, Provo, UT 84602 USA;Tazi, L (reprint author), Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Brownsville Reg Campus, Brownsville, TX USA
    1. Year: 2011
    2. Date: Mar
  2. Journal: Bmc Evolutionary Biology
    1. 11
    2. Pages: 9
  4. Type of Article: Article
  5. Article Number: 62
  6. ISSN: 1471-2148
  1. Abstract:

    Background: Replicate experiments are often difficult to find in evolutionary biology, as this field is inherently an historical science. However, viruses, bacteria and phages provide opportunities to study evolution in both natural and experimental contexts, due to their accelerated rates of evolution and short generation times. Here we investigate HIV-1 evolution by using a natural model represented by monozygotic twins infected synchronically at birth with an HIV-1 population from a shared blood transfusion source. We explore the evolutionary processes and population dynamics that shape viral diversity of HIV in these monozygotic twins. Results: Despite the identical host genetic backdrop of monozygotic twins and the identical source and timing of the HIV-1 inoculation, the resulting HIV populations differed in genetic diversity, growth rate, recombination rate, and selection pressure between the two infected twins. Conclusions: Our study shows that the outcome of evolution is strikingly different between these two "replicates" of viral evolution. Given the identical starting points at infection, our results support the impact of random epigenetic selection in early infection dynamics. Our data also emphasize the need for a better understanding of the impact of host-virus interactions in viral evolution.

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External Sources

  1. View Full Text
  2. DOI: 10.1186/1471-2148-11-62
  3. View record in Web of Science®
  4. WOS: 000289413900002

Library Notes

  1. Fiscal Year: FY2010-2011
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