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Mouse Ly49G2(+) NK cells dominate early responses during both immune reconstitution and activation independently of MHC

  1. Author:
    Barao, I.
    Alvarez, M.
    Ames, E.
    Orr, M. T.
    Stefanski, H. E.
    Blazar, B. R.
    Lanier, L. L.
    Anderson, S. K.
    Redelman, D.
    Murphy, W. J.

  2. Author Address

    [Murphy, WJ] Univ Calif Davis, Dept Dermatol, Sch Med, CTSC IRC, Sacramento, CA 95817 USA [Barao, I] Univ Nevada, Dept Microbiol & Immunol, Reno, NV 89557 USA [Orr, MT; Lanier, LL] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA [Orr, MT; Lanier, LL] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA [Stefanski, HE; Blazar, BR] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA [Stefanski, HE; Blazar, BR] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA [Anderson, SK] NCI, Frederick, MD 21701 USA [Anderson, SK] SAIC Frederick Inc, Lab Expt Immunol, Canc & Inflammat Program, Frederick, MD USA [Redelman, D] Univ Nevada, Dept Physiol, Reno, NV 89557 USA [Murphy, WJ] Univ Calif Davis, Dept Internal Med, Sacramento, CA USA;Murphy, WJ (reprint author), Univ Calif Davis, Dept Dermatol, Sch Med, CTSC IRC, Suite 1630,2921 Stockton Blvd, Sacramento, CA 95817 USA;wmjmurphy@ucdavis.edu
    1. Year: 2011
    2. Date: Jun
  2. Journal: Blood
    1. 117
    2. 26
    3. Pages: 7032-7041
  4. Type of Article: Article
  5. ISSN: 0006-4971
  1. Abstract:

    Natural killer (NK) cell subsets can be defined by the differential expression of inhibitory receptors for MHC class I molecules. Early after congenic HSCT, we found that Ly49G2(high) single-positive NK cells repopulated, displayed an activated phenotype, and were highly cytolytic. Over time, this subset was replaced with NK cells with a normal pattern of Ly49 expression. Treatment of mice with IL-2 also resulted in the rapid expansion of these Ly49G2(high) single-positive NK cells. Only the Ly49g (Klra7) Pro1 transcript was highly induced in both HSCT- and IL-2-treated recipients. MHC-independent expansion of the Ly49G2(+) subset was also observed after Listeria monocytogenes or mouse cytomegalovirus infection. Our data indicate that during reconstitution after HSCT and various activation stimuli, Ly49G2(+) NK cells represent the "first-responder" NK cells, which occur independently of NK-cell licensing via Ly49-MHC interactions. These data suggest that the inhibitory Ly49G2 receptor represents an activation marker on mouse NK cells under various conditions. (Blood. 2011;117(26):7032-7041)

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External Sources

  1. View Full Text
  2. DOI: 10.1182/blood-2010-11-316653
  3. View record in Web of Science®
  4. WOS: 000292244000011

Library Notes

  1. Fiscal Year: FY2010-2011
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