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The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

  1. Author:
    Abi-Rached, L.
    Jobin, M. J.
    Kulkarni, S.
    McWhinnie, A.
    Dalva, K.
    Gragert, L.
    Babrzadeh, F.
    Gharizadeh, B.
    Luo, M.
    Plummer, F. A.
    Kimani, J.
    Carrington, M.
    Middleton, D.
    Rajalingam, R.
    Beksac, M.
    Marsh, S. G. E.
    Maiers, M.
    Guethlein, L. A.
    Tavoularis, S.
    Little, A. M.
    Green, R. E.
    Norman, P. J.
    Parham, P.

  2. Author Address

    [Abi-Rached, L; Kulkarni, S; Guethlein, LA; Norman, PJ; Parham, P] Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA. [Abi-Rached, L; Kulkarni, S; Guethlein, LA; Norman, PJ; Parham, P] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA. [Jobin, MJ] Santa Clara Univ, Dept Anthropol, Santa Clara, CA 95050 USA. [Jobin, MJ] Stanford Univ, Dept Anthropol, Stanford, CA 94305 USA. [McWhinnie, A; Marsh, SGE; Little, AM] Royal Free Hosp, Anthony Nolan Res Inst, London NW3 2QG, England. [Dalva, K; Beksac, M] Ankara Univ, Dept Hematol, TR-06520 Ankara, Turkey. [Gragert, L; Maiers, M] Natl Marrow Donor Program, Minneapolis, MN 55413 USA. [Babrzadeh, F; Gharizadeh, B] Stanford Univ, Sch Med, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA. [Luo, M; Plummer, FA] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada. [Luo, M; Plummer, FA] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0J9, Canada. [Kimani, J] Univ Nairobi, Dept Med Microbiol, Nairobi 00202, Kenya. [Carrington, M] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD 21702 USA. [Carrington, M] Ragon Inst MGH MIT & Harvard, Boston, MA 02129 USA. [Middleton, D] Univ Liverpool, Royal Liverpool Univ Hosp, Sch Infect & Host Def, Div Immunol, Liverpool L7 8XP, Merseyside, England. [Rajalingam, R] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, UCLA Immunogenet Ctr, Los Angeles, CA 90095 USA. [Marsh, SGE; Little, AM] UCL, UCL Canc Inst, London WC1E 6BT, England. [Tavoularis, S] Canadian Blood Serv, Head Off, HLA Lab, Ottawa, ON K1G 4J5, Canada. [Green, RE] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA.;Parham, P (reprint author), Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA;peropa@stanford.edu
    1. Year: 2011
    2. Date: Oct
  2. Journal: Science
    1. 333
    2. 6052
    3. Pages: 89-94
  4. Type of Article: Article
  5. ISSN: 0036-8075
  1. Abstract:

    Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals. Virtual genotyping of Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive alleles that have introgressed into modern Eurasian and Oceanian populations. These alleles, of which several encode unique or strong ligands for natural killer cell receptors, now represent more than half the HLA alleles of modern Eurasians and also appear to have been later introduced into Africans. Thus, adaptive introgression of archaic alleles has significantly shaped modern human immune systems.

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External Sources

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  2. DOI: 10.1126/science.1209202
  3. View record in Web of Science®
  4. WOS: 000295580300046

Library Notes

  1. Fiscal Year: FY2011-2012
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