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Simian hemorrhagic fever virus infection of rhesus macaques as a model of viral hemorrhagic fever: Clinical characterization and risk factors for severe disease

  1. Author:
    Johnson, R. F.
    Dodd, L. E.
    Yellayi, S.
    Gu, W. J.
    Cann, J. A.
    Jett, C.
    Bernbaum, J. G.
    Ragl, D. R.
    St Claire, M.
    Byrum, R.
    Paragas, J.
    Blaney, J. E.
    Jahrling, P. B.

  2. Author Address

    [Johnson, RF; Blaney, JE; Jahrling, PB] NIAID, NIH, EVPS, Bethesda, MD 20892 USA. [Dodd, LE] NIAID, Biostat Res Branch, NIH, Frederick, MD 21702 USA. [Yellayi, S; Cann, JA; Jett, C; Bernbaum, JG; Ragland, DR; St Claire, M; Byrum, R; Paragas, J; Jahrling, PB] NIAID, Integrated Res Facil, NIH, Frederick, MD 21702 USA. [Gu, WJ] NCI, SAIC Frederick Inc, Biostat Res Branch, Frederick, MD 21702 USA.;Johnson, RF (reprint author), NIAID, NIH, EVPS, Bldg 33 Rm 2E19A,33 North Dr, Bethesda, MD 20892 USA;johnsonreed@mail.nih.gov
    1. Year: 2011
    2. Date: Dec
  2. Journal: Virology
    1. 421
    2. 2
    3. Pages: 129-140
  4. Type of Article: Article
  5. ISSN: 0042-6822
  1. Abstract:

    Simian Hemorrhagic Fever Virus (SHFV) has caused sporadic outbreaks of hemorrhagic fevers in macaques at primate research facilities. SHFV is a BSL-2 pathogen that has not been linked to human disease; as such, investigation of SHFV pathogenesis in non-human primates (NHPs) could serve as a model for hemorrhagic fever viruses such as Ebola, Marburg, and Lassa viruses. Here we describe the pathogenesis of SHFV in rhesus macaques inoculated with doses ranging from 50 PFU to 500,000 PFU. Disease severity was independent of dose with an overall mortality rate of 64% with signs of hemorrhagic fever and multiple organ system involvement Analyses comparing survivors and non-survivors were performed to identify factors associated with survival revealing differences in the kinetics of viremia, immunosuppression, and regulation of hemostasis. Notable similarities between the pathogenesis of SHFV in NHPs and hemorrhagic fever viruses in humans suggest that SHFV may serve as a suitable model of BSL-4 pathogens. Published by Elsevier Inc.

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External Sources

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  2. DOI: 10.1016/j.virol.2011.09.016
  3. View record in Web of Science®
  4. WOS: 000297183900006

Library Notes

  1. Fiscal Year: FY2011-2012
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