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Targeted mass spectrometry approaches for protein biomarker verification

  1. Author:
    Meng, Z. J.
    Veenstra, T. D.

  2. Author Address

    [Meng, Zhaojing; Veenstra, Timothy D.] NCI, Lab Prote & Analyt Technol, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA.;Veenstra, TD (reprint author), NCI, Lab Prote & Analyt Technol, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA;veenstra@ncifcrf.gov
    1. Year: 2011
    2. Date: Nov
  2. Journal: Journal of Proteomics
    1. 74
    2. 12
    3. Pages: 2650-2659
  4. Type of Article: Review
  5. ISSN: 1874-3919
  1. Abstract:

    The search for protein biomarkers has been a highly pursued topic in the proteomics community in the last decade. This relentless search is due to the constant need for validated biomarkers that could facilitate disease risk stratification, disease diagnosis, prognosis, monitoring as well as drug development, which ultimately would improve our quality of life. The recent development of proteomic technologies including the advancement of mass spectrometers with high sensitivity and speed has greatly advanced the discovery of potential biomarkers. One of the bottlenecks lies in the development of well-established verification assays to screen the biomarker candidates identified in the discovery stage. Recently, absolute quantitation using multiple-reaction monitoring mass spectrometry (MRM-MS) in combination with isotope-labeled internal standards has been extensively investigated as a tool for high-throughput protein biomarker verification. In this review, we describe and discuss recent developments and applications of MRM-MS methods for biomarker verification. (C) 2011 Elsevier B.V. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.jprot.2011.04.011
  3. View record in Web of Science®
  4. WOS: 000298305900008

Library Notes

  1. Fiscal Year: FY2011-2012
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