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Regulation of IFN-gamma Expression

  1. Author:
    Fenimore, John
    Young, Howard

  2. Author Address

    National Cancer Institute at Frederick, Cancer and Inflammation Program, Center for Cancer Research, Frederick, MD, 21702, USA. john.fenimore@nih.gov. National Cancer Institute at Frederick, Cancer and Inflammation Program, Center for Cancer Research, Frederick, MD, 21702, USA.
    1. Year: 2016
    2. Epub Date: 10/14/2016
  2. Journal: Advances in Experimental Medicine and Biology
    1. 941
    2. Pages: 1-19
  4. Type of Article: Article
  5. ISSN: 0065-2598 (Print) 0065-2598
  1. Abstract:

    Interferon gamma, referred to here as IFN-gamma, is a major component in immunological cell signaling and is a critical regulatory protein for overall immune system function. First discovered in 1965 (Wheelock Science 149: (3681)310-311, 1965), IFN-gamma is the only Type II interferon identified. Its expression is both positively and negatively controlled by different factors. In this chapter, we will review the transcriptional and post-transcriptional control of IFN-gamma expression. In the transcriptional control part, the regular activators and suppressors are summarized, we will also focus on the epigenetic control, such as chromosome access, DNA methylation, and histone acetylation. The more we learn about the control of this regulatory protein will allow us to apply this knowledge in the future to effectively manipulate IFN-gamma expression for the treatment of infections, cancer, inflammation, and autoimmune diseases.

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External Sources

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  2. DOI: 10.1007/978-94-024-0921-5_1
  3. PMID: 27734406
  4. View record in Web of Science®
  5. WOS: 000401016400001

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