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3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy

  1. Author:
    Lester, D. S.
    Lyon, R. C.
    McGregor, G. N.
    Engelhardt, R. T.
    Schmued, L. C.
    Johnson, G. A.
    Johannessen, J. J.

  2. Author Address

    Lester DS US FDA, Div Appl Pharmacol Res 8301 Muirkirk Rd,Rm 2009 Laurel, MD 20708 USA US FDA, Div Appl Pharmacol Res Laurel, MD 20708 USA US FDA, Div Prod Qual Res, Ctr Drug Evaluat & Res Laurel, MD 20708 USA US FDA, Ctr Food Safety & Appl Nutr Laurel, MD 20708 USA NCI, Frederick Biomed Supercomp Ctr, SAIC Frederick, FCRDC Frederick, MD USA Duke Univ, Med Ctr, Ctr In Vivo Microscopy Durham, NC USA US FDA, Div Neurotoxicol, Natl Ctr Toxicol Res Jefferson, AR 72079 USA
    1. Year: 1999
  2. Journal: Neuroreport
    1. 10
    2. 4
    3. Pages: 737-741
  4. Type of Article: Article
  1. Abstract:

    HIGH-RESOLUTION (< 50 mu m) magnetic resonance imaging microscopy (MRM) has been used to identify brain regions and localization of excitotoxin-induced lesions in fixed rat brains, subsequently confirmed using standard histology. The anatomical extent of lesions identified by MRM Nas identical to that seen in histological sections and various histopathological changes could be visualized. In contrast to the time involved in preparing and examining histological sections, lesions in intact brains could be rapidly identified and visualized in three dimensions by examining digitally generated sections in any plane. This study shows that MRM has tremendous potential as a prescreening tool for neurotoxicity and neuropathology. These observations suggest that MRM has the potential to affect pathology much as conventional MRI has influenced clinical imaging. NeuroReport 10:737-741 (C) 1999 Lippincott Williams & Wilkins. [References: 14]

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