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The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells

  1. Author:
    Yao, Xiaohong
    Chen, Keqiang
    Wang, Xiafei
    Zhou, Jiamin
    Gong, Wanghua
    Yoshimura, Teizo
    Huang, Jiaqiang
    Wang, Rongquan
    Wu, Yuzhang
    Shi, Guochao
    Bian, Xiuwu
    Wang, Jiming

  2. Author Address

    Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Pulm Med, Shanghai 200025, Peoples R China.NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.Third Mil Med Univ, Inst Pathol, Chongqing 400038, Peoples R China.Third Mil Med Univ, Southwest Canc Ctr, Chongqing 400038, Peoples R China.Fudan Univ, Shanghai Canc Ctr, Dept Liver Surg, Shanghai 200032, Peoples R China.Leidos Biomed Res Inc, Basic Res Program, Frederick, MD 21702 USA.Beijing Jiaotong Univ, Sch Sci, Coll Life Sci & Bioengn, Beijing 100044, Peoples R China.Third Mil Med Univ, Southwest Hosp, Dept Gastroenterol, Chongqing 400038, Peoples R China.Third Mil Med Univ, Inst Immunol, Chongqing 400038, Peoples R China.
    1. Year: 2016
    2. Epub Date: 2016 Nov 1
  2. Journal: AMERICAN JOURNAL OF CANCER RESEARCH
  3. E-CENTURY PUBLISHING CORP,
    1. 6
    2. 11
    3. Pages: 2599-+
  5. Type of Article: Article
  6. ISSN: 2156-6976
  1. Abstract:

    The G-protein coupled chemoattractant receptor formylpeptide receptor-2 (FPR2 in human, Fpr2 in mice) is expressed by mouse colon epithelial cells and plays a critical role in mediating mucosal homeostasis and inflammatory responses. However, the biological role of FPR2 in human colon is unclear. Our investigation revealed that a considerable number of human colon cancer cell lines expressed FPR2 and its ligands promoted cell migration and proliferation. Human colon cancer cell lines expressing high levels of FPR2 also formed more rapidly growing tumors in immunocompromised mice as compared with cell lines expressing lower levels of FPR2. Knocking down of FPR2 from colon cancer cell lines highly expressing FPR2 reduced their tumorigenicity. Clinically, FPR2 is more highly expressed in progressive colon cancer, associated with poorer patient prognosis. These results suggest that FPR2 can be high-jacked by colon cancer cells for their growth advantage, thus becoming a potential target for therapeutic development.

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  1. Keywords:

External Sources

  1. PMID: 27904774
  2. PMCID: PMC5126276
  3. View record in Web of Science®
  4. WOS: 000390591500015

Library Notes

  1. Fiscal Year: FY2016-2017
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