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RAS Proteins and Their Regulators in Human Disease

  1. Author:
    Simanshu, Dhirendra
    Nissley, Dwight
    McCormick, Frank

  2. Author Address

    NCI, RAS Initiat, Canc Res Technol Program, Frederick Natl Lab Canc Res,Leidos Biomed Res, Frederick, MD 21701 USA.Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, 1450 3rd St, San Francisco, CA 94158 USA.
    1. Year: 2017
    2. Date: Jun 29
  2. Journal: Cell
  3. CELL PRESS,
    1. 170
    2. 1
    3. Pages: 17-33
  5. Type of Article: Article
  6. ISSN: 0092-8674
  1. Abstract:

    RAS proteins are binary switches, cycling between ON and OFF states during signal transduction. These switches are normally tightly controlled, but in RAS-related diseases, such as cancer, RASopathies, and many psychiatric disorders, mutations in the RAS genes or their regulators render RAS proteins persistently active. The structural basis of the switch and many of the pathways that RAS controls are well known, but the precise mechanisms by which RAS proteins function are less clear. All RAS biology occurs in membranes: a precise understanding of RAS' interaction with membranes is essential to understand RAS action and to intervene in RAS-driven diseases.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.cell.2017.06.009
  3. PMID: 28666118
  4. PMCID: PMC5555610
  5. View record in Web of Science®
  6. WOS: 000404358500007

Library Notes

  1. Fiscal Year: FY2016-2017
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