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Effects of low-to-moderate alcohol supplementation on urinary estrogen metabolites in postmenopausal women in a controlled feeding study.

  1. Author:
    Mahabir, Somdat [ORCID]
    Pfeiffer, Ruth
    Xu, Xia
    Baer, David J
    Taylor, Philip R

  2. Author Address

    Environmental Epidemiology Branch, Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute (NCI), Rockville, Maryland., Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland., Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland., Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland., Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland.,
    1. Year: 2017
    2. Date: Oct
    3. Epub Date: 2017 Sep 06
  2. Journal: Cancer medicine
    1. 6
    2. 10
    3. Pages: 2419-2423
  4. Type of Article: Article
  5. ISSN: 2045-7634
  1. Abstract:

    Heavy alcohol drinking is associated with increased breast cancer risk, but associations with low-to-moderate alcohol consumption are less clear and the biological mechanisms are not well defined. The objective of this study was to evaluate the effects of 8 weeks of low (15 g/d) and moderate (30 g/d) alcohol ingestion on concentrations of 15 urinary estrogen metabolites (EMs) in postmenopausal women (n = 51) in a controlled feeding study with a randomized crossover design. Compared to no alcohol, 15 g/day for 8 weeks had no effect on urinary EMs. However, compared to no alcohol, 30 g/day for 8 weeks decreased urinary 2-hydroestrone (2-OHE1) by 3.3% (P = 0.055) and increased 16-epiestriol (16-EpiE3) by 26.6% (P = 0.037). Trends for reduced urinary 2-OHE1 (P = 0.045), reduced ratio of 2-OH:16OH pathways (P = 0.008), and increased 16-EpiE3 (P = 0.035) were observed as alcohol ingestion increased from 0 g to 15 g to 30 g/d. Moderate alcohol consumption for 8 weeks had modest effects on urinary concentrations of 2-OHE1 and 16-EpiE3 among postmenopausal women in a carefully controlled feeding study. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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External Sources

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  2. DOI: 10.1002/cam4.1153
  3. PMID: 28879665
  4. View record in Web of Science®
  5. WOS: 000412646000024

Library Notes

  1. Fiscal Year: FY2016-2017
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