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Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda

  1. Author:
    Juan, Ravell
    Otim, Isaac
    Nabalende, Hadijah
    Legason, Ismail D
    Reynolds, Steven J
    Ogwang, Martin D
    Ndugwa, Christopher M
    Marshall, Vickie
    Whitby, Denise
    Goedert, Jim
    Engels, Eric A
    Bhatia, Kishor
    Lenardo, Michael J
    Mbulaiteye, Sam M

  2. Author Address

    Molecular Development of the Immune System Section, Laboratory of Immune System Biology and Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA., EMBLEM Study, St. Mary 39;s Hospital, Lacor, PO Box 180 Gulu, Uganda., Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA., Makerere University Medical School and Mulago Hospital, PO Box 7072 Kampala, Uganda., Viral Oncology AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, 21701, USA., Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, 20892, USA., Molecular Development of the Immune System Section, Laboratory of Immune System Biology and Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA. Electronic address: lenardo@nih.gov., Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, 20892, USA. Electronic address: mbulaits@mail.nih.gov.,
    1. Year: 2018
    2. Date: Feb
    3. Epub Date: 2017 12 14
  2. Journal: Cancer Epidemiology
    1. 52
    2. Pages: 70-74
  4. Type of Article: Article
  5. ISSN: 1877-7821
  1. Abstract:

    Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Plasma Mg2+ deficiency (plasma level < 1.8?mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14-60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32-9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Plasma Mg2+ deficiency is associated with high EBV levels and eBL. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.canep.2017.12.004
  3. PMID: 29248801
  4. View record in Web of Science®
  5. WOS: 000425089700009
  6. PII : S1877-7821(17)30203-5

Library Notes

  1. Fiscal Year: FY2017-2018
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