Skip NavigationSkip to Content
Return Return to Search Results

Crystal structure of N-{N-[N-acetyl-(S)-leuc-yl]-(S)-leuc-yl}norleucinal (ALLN), an inhibitor of proteasome

  1. Author:
    Czerwinski, Andrzej
    Basava, Channa
    Dauter, Miroslawa
    Dauter, Zbigniew

  2. Author Address

    Peptides International, Inc., 11621 Electron Drive, Louisville, KY 40299, USA., Leidos Biomedical Research Inc., Basic Science Program, Argonne National Laboratory, Argonne, IL 60439, USA., Synchrotron Radiation Research Section, MCL, National Cancer Institute, Argonne National Laboratory, Argonne, IL 60439, USA.,
    1. Year: 2015
    2. Date: Mar 01
    3. Epub Date: 2015 02 07
  2. Journal: Acta crystallographica. Section E, Crystallographic communications
    1. 71
    2. Pt 3
    3. Pages: 254-7
  4. Type of Article: Article
  1. Abstract:

    The title compound, C20H37N3O4, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. The crystal structure of ALLN, solved from synchrotron radiation diffraction data, revealed the mol-ecules in extended conformation of the backbone and engaging all peptide N and O atoms in inter-molecular hydrogen bonds forming an infinite anti-parallel ß-sheet.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1107/S2056989015002091
  3. PMID: 25844180
  4. PMCID: PMC4350719
  5. PII : gk2625

Library Notes

  1. Fiscal Year: FY2014-2015
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel