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Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity

  1. Author:
    Gao, Bo [ORCID]
    Ajima, Rieko
    Yang, Wei
    Li, Chunyu
    Song, Hai
    Anderson, Matthew
    Liu, Robert R
    Lewandoski, Mark
    Yamaguchi, Terry P
    Yang, Yingzi [ORCID]

  2. Author Address

    School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China yingzi_yang@hsdm.harvard.edu gaobo@hku.hk., Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD 21702, USA., School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China., China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China., Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave., Boston, MA 02115, USA yingzi_yang@hsdm.harvard.edu gaobo@hku.hk.,
    1. Year: 2018
    2. Date: Apr 13
    3. Epub Date: 2018 04 03
  2. Journal: Development (Cambridge, England)
    1. 145
    2. 8
    3. Pages: pii: dev.163824
  4. Type of Article: Article
  5. Article Number: dev163824
  6. ISSN: 0950-1991
  1. Abstract:

    Embryonic morphogenesis of a complex organism requires proper regulation of patterning and directional growth. The Planar Cell Polarity (PCP) signaling is emerging as a critical evolutionarily conserved mechanism whereby directional information is conveyed. PCP is thought to be established by global cues, and recent studies have revealed an instructive role of Wnt signaling gradient in epithelia tissues of both invertebrates and vertebrates. However, it remains unclear whether Wnt/PCP signaling is coordinately regulated with embryonic patterning during morphogenesis. Here in the mammalian developing limbs, we find that the AER-derived Fgfs required for limb patterning regulates PCP along the proximal-distal axis in a Wnt5a-dependent manner. We demonstrate with genetic evidence that Wnt5a gradient acts as a global cue that is instructive in establishing PCP in the limb mesenchyme, while Wnt5a also plays a permissive role to allow Fgf signaling to orient PCP. Our results indicate that limb morphogenesis is critically regulated by coordination of directional growth and patterning through integrating Wnt5a and Fgf signaling in PCP regulation. © 2018. Published by The Company of Biologists Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1242/dev.163824
  3. PMID: 29615464
  4. PMCID: PMC5964654
  5. View record in Web of Science®
  6. WOS: 000438945600011
  7. PII : dev.163824

Library Notes

  1. Fiscal Year: FY2017-2018
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