Skip NavigationSkip to Content
Return Return to Search Results

T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor

  1. Author:
    Su, S. B.
    Gong, W. H.
    Gao, J. L.
    Shen, W. P.
    Grimm, M. C.
    Deng, X. Y.
    Murphy, P. M.
    Oppenheim, J. J.
    Wang, J. M.

  2. Author Address

    Wang JM NCI, Lab Mol Immunoregulat, Div Basic Sci, SAIC Frederick,Frederick Canc Res & Dev Ctr Bldg 560,Room 31-40 Frederick, MD 21702 USA NCI, Lab Mol Immunoregulat, Div Basic Sci, SAIC Frederick,Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA NCI, Intramural Res Support Program, SAIC Frederick, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Blood
    1. 93
    2. 11
    3. Pages: 3885-3892
  4. Type of Article: Article
  1. Abstract:

    Human immunodeficiency virus type 1 (HIV-1) envelope protein gp41 mediates viral fusion with human host cells. The peptide segment T20/DP178, located in the C-terminus of the ectodomain of gp41, interacts with the N-terminal leucine zipper-like domain on 9941 to establish the fusogenic conformation of the virus. Synthetic T20/DP178 peptide is highly efficacious in inhibiting HIV-1 infection in vitro by disrupting the transformation of fusogenic status of viral gp41; thus, it has been proposed for clinical trial. We report that synthetic T20/DP178 is a chemoattractant and activator of human peripheral blood phagocytes but not of T lymphocytes. We further demonstrate that T20/DP178 specifically activates a seven-transmembrane, G-protein-coupled phagocyte receptor for N-formylated chemotactic peptides, formyl peptide receptor (FPR), Moreover, synthetic T20/DP178 analogs lacking N-terminal amino acids acted as FPR antagonists. Our results suggest that gp41 peptides regulate phagocyte function via FPR and identify a novel mechanism by which HIV-1 may modulate innate immunity. (C) 1999 by The American Society of Hematology. [References: 47]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel