Skip NavigationSkip to Content
Return Return to Search Results

Single nucleotide polymorphisms in HLA alleles are associated with HIV-1 viral load in demographically diverse, ART-naïve participants from the START trial

  1. Author:
    Ekenberg, Christina
    Tang, Man-Hung Eric
    Zucco, Adrian G
    Murray, Daniel D
    MacPherson, Cameron Ross
    Hu,Xiaojun
    Sherman,Brad
    Losso, Marcelo H
    Wood, Robin
    Paredes, Roger
    Molina, Jean-Michel
    Helleberg, Marie
    Jina, Nureen
    Kityo, Cissy M
    Florence, Eric
    Polizzotto, Mark N
    Neaton, James D
    Lane, H Clifford
    Lundgren, Jens D

  2. Author Address

    Centre of Excellence for Health, Immunity and Infections (CHIP), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., Hospital General de Agudos JM Ramos, Buenos Aires, Argentina., Desmond Tutu HIV Foundation Clinical Trials Unit, Cape Town, South Africa., Infectious Diseases Service & irsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Catalonia, Spain., Department of Infectious Diseases, University of Paris Diderot, Sorbonne Paris Cit 233;, Paris, France; H 244;pital Saint-Louis, Assistance Publique-H 244;pitaux de Paris, Paris, France., Clinical HIV Research Unit, Wits Health Consortium, Department of Medicine, University of the Witwatersrand, Helen Joseph Hospital, Themba Lethu Clinic, Johannesburg, South Africa., Joint Clinical Research Centre, Kampala, Uganda., Institute of Tropical Medicine, Antwerp, Belgium., Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia., Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA., National Institute of Allergy and Infectious Diseases, Division of Clinical Research, Bethesda, Maryland, USA.,
    1. Year: 2019
    2. Date: OCT 15
    3. Epub Date: 2019 06 13
  2. Journal: The Journal of infectious diseases
    1. 220
    2. 8
    3. Pages: 1325-1334
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    The impact of variation in host genetics on replication of HIV-1 in demographically diverse populations remains uncertain. Here, we perform a genome-wide screen for associations of single nucleotide polymorphisms (SNP) to viral load (VL) in antiretroviral therapy-naïve participants (n=2,440) with varying demographics from the Strategic Timing of AntiRetroviral Treatment (START) trial. Associations were assessed using genotypic data generated by a customized SNP array, imputed human leukocyte antigen (HLA) alleles and multiple linear regression. Genome-wide significant associations between SNPs and VL were observed in the major histocompatibility complex (MHC) class I region with effect sizes ranging between 0.14-0.39 log10 VL. Supporting the SNP findings, we identified several HLA alleles significantly associated with VL, extending prior observations that the MHC I region is a major host determinant of HIV-1 control with shared genetic variants across diverse populations and underscoring the limitations of GWAS being merely a screening tool. © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/infdis/jiz294
  3. PMID: 31219150
  4. View record in Web of Science®
  5. WOS: 000490988000012
  6. PII : 5521002

Library Notes

  1. Fiscal Year: FY2018-2019
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel