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Transforming Growth Factor-Beta-1 in Adult Human Microglia and Its Stimulated Production By Interleukin-1

  1. Author:
    Dacunha, A.
    Jefferson, J. J.
    Tyor, W. R.
    Glass, J. D.
    Jannotta, F. S.
    Cottrell, J. R.
    Resau, J. H.

  2. Author Address

    Dacunha A GEORGETOWN UNIV DEPT BIOL POB 30166 BETHESDA, MD 20824 USA NIMH CELL BIOL LAB NIH BETHESDA, MD 20892 USA NCI PATHOL LAB NIH BETHESDA, MD 20892 USA MED UNIV S CAROLINA DEPT NEUROL CHARLESTON, SC 29425 USA JOHNS HOPKINS UNIV SCH MED BALTIMORE, MD USA GEORGE WASHINGTON UNIV MED CTR DEPT PATHOL WASHINGTON, DC 20037 USA UNIV MARYLAND SCH MED BALTIMORE, MD 21201 USA NCI ABL BASIC RES PROGRAM FREDERICK CANC RES & DEV CTR FREDERICK, MD USA
    1. Year: 1997
  2. Journal: Journal of Interferon and Cytokine Research
    1. 17
    2. 11
    3. Pages: 655-664
  4. Type of Article: Article
  1. Abstract:

    Ameboid microglia express human immunodeficiency virus 1 (HIV-1) more frequently than do ramified microglia, These two microglial subtypes might also differ in the frequency with which they express transforming growth factor-beta 1 (TGF-beta 1), a cytokine that regulates HIV-1 expression in monocytes. Results described here show that ameboid and ramified microglia express TGF-beta 1. In brain tissues from HIV-1-infected individuals as compared with seronegative controls, ameboid rather than ramified microglia more frequently expressed TGF-beta 1, Ameboid microglia, isolated and cultured from postmortem adult human brain more frequently expressed TGF-beta 1 in presence of interleukin-1(IL-1), a cytokine that is elevated in brains of HIV-1-infected individuals when compared with seronegative controls. The stimulation of TGF-beta 1 by IL-1 was dose and time dependent, occurring with ameboid microglia isolated from either frontal cortex or globus pallidus but not midbrain pens, Ameboid microglia are similar to the RCA-1-positive cells that form clusters, called microglial nodules, in the brain of HIV-1-infected individuals. Pathologic conditions, such as disseminated microglial nodules, are associated with HIV-1 encephalitis, direct infection of the brain, and moderate to severe neurologic impairment. TGF-beta 1 expression in ameboid microglia may play a role in HIV-1 neuropathogenesis. [References: 69]

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