Skip NavigationSkip to Content
Return Return to Search Results

Dub-2 Is a Member of a Novel Family of Cytokine-Inducible Deubiquitinating Enzymes

  1. Author:
    Zhu, Y. A.
    Lambert, K.
    Corless, C.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    D, rea

  2. Author Address

    Dandrea AD HARVARD UNIV SCH MED DANA FARBER CANC INST DIV PEDIAT ONCOL 44 BINNEY ST BOSTON, MA 02115 USA HARVARD UNIV SCH MED DANA FARBER CANC INST DIV PEDIAT ONCOL BOSTON, MA 02115 USA HARVARD UNIV SCH MED DANA FARBER CANC INST DIV CELLULAR & MOL BIOL BOSTON, MA 02115 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM MAMMALIAN GENET LAB FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Biological Chemistry
    1. 272
    2. 1
    3. Pages: 51-57
  4. Type of Article: Article
  1. Abstract:

    Cytokines regulate cell growth by inducing the expression of specific target genes. We have recently identified a cytokine-inducible, immediate-early gene, DUB-1, that encodes a deubiquitinating enzyme with growth regulatory activity. In the current study, we have isolated a highly related gene, DUB-2, that is induced by interleukin-2. The DUB-2 mRNA was induced in T cells as an immediate-early gene and was rapidly down-regulated. Like DUB-1, the DUB-2 protein had deubiquitinating activity in vitro. When a conserved cysteine residue of DUB-2, required for ubiquitin-specific thiol protease activity, was mutated to serine (C60S), deubiquitinating activity was abolished. DUB-1 and DUB-2 proteins are highly related throughout their primary amino acid sequence except for a hypervariable region at their COOH terminus. Moreover, the DUB genes co-localize to a region of mouse chromosome 7, suggesting that they arose by a tandem duplication of an ancestral DUB gene. Additional DUB genes co-localize to this region, suggesting a larger family of cytokine-inducible DUB enzymes. We propose that different cytokines induce specific DUB genes. Each induced DUB enzyme thereby regulates the degradation or the ubiquitination state of an unknown growth regulatory factor, resulting in a cytokine-specific growth response. [References: 53]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel