Skip NavigationSkip to Content
Return Return to Search Results

The Regulatory Role of MicroRNA in Hepatitis-B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) Pathogenesis

  1. Author:
    Sartorius, Kurt
    Makarova, Julia
    Sartorius, Benn
    An,Ping
    Winkler,Cheryl
    Chuturgoon, Anil
    Kramvis, Anna

  2. Author Address

    Univ KwaZulu Natal, Sch Nursing & Publ Hlth, Dept Publ Hlth Med, ZA-4041 Durban, South Africa.Univ Witwatersrand, Fac Commerce Law & Management, ZA-2193 Johannesburg, South Africa.UKZN Gastrointestinal Canc Res Ctr, ZA-4041 Durban, South Africa.Minist Hlth Russian Federat, Natl Med Res Radiol Ctr, Hertsen Moscow Oncol Res Inst, Moscow 125284, Russia.Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia.Natl Res Univ Higher Sch Econ, Fac Biol & Biotechnol, Moscow 101000, Russia.NCI, Frederick Natl Lab, Basic Res Lab, Ctr Canc Res, Frederick, MD 21702 USA.Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Hepatitis Virus Divers Res Unit,Dept Internal Med, ZA-2193 Johannesburg, South Africa.
    1. Year: 2019
    2. Date: DEC
    3. Epub Date: 2019 11 24
  2. Journal: Cells
  3. MDPI,
    1. 8
    2. 12
  5. Type of Article: Review
  6. Article Number: 1504
  7. ISSN: 2073-4409
  1. Abstract:

    The incidence and mortality of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HBV-HCC) is an intractable public health problem in developing countries that is compounded by limited early detection and therapeutic options. Despite the early promise of utilizing the regulatory role of miRNA in liver cancer, this field remains largely in the work-in-progress phase. This exploratory review paper adopts a broad focus in order to collate evidence of the regulatory role of miRNA in each stage of the HBV-HCC continuum. This includes the regulatory role of miRNA in early HBV infection, chronic inflammation, fibrosis/cirrhosis, and the onset of HCC. The paper specifically investigates HBV dysregulated miRNA that influence the expression of the host/HBV genome in HBV-HCC pathogenesis and fully acknowledges that this does not cover the full spectrum of dysregulated miRNA. The sheer number of dysregulated miRNA in each phase support a hypothesis that future therapeutic interventions will need to consider incorporating multiple miRNA panels.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.3390/cells8121504
  3. View record in Web of Science®
  4. WOS: 000506643500033

Library Notes

  1. Fiscal Year: FY2019-2020
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel