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A unique immune signature of serum cytokine and chemokine dynamics in patients with zika virus infection from a tropical region in Southern Mexico

  1. Author:
    Zuñiga, Joaquín
    Choreño-Parra, José Alberto
    Jiménez-Alvarez, Luis
    Cruz-Lagunas, Alfredo
    Márquez, José Eduardo
    Ramírez-Martínez, Gustavo
    Goodina, Aminadab
    Hernández-Montiel, Erika
    Fernández-López, Luis Alejandro
    Cabrera-Cornejo, María Fernanda
    Cabello, Carlos
    Castillejos, Manuel
    Hernández, Andrés
    Regino-Zamarripa, Nora E
    Mendoza-Milla, Criselda
    Vivanco-Cid, Héctor
    Escobar-Gutierrez, Alejandro
    Fonseca, Salvador
    Belaunzarán-Zamudio, Pablo F
    Pérez-Patrigeon, Santiago
    Guerrero, Lourdes
    Regalado, Justino
    Nájera-Cancino, Gabriel
    Caballero-Sosa, Sandra
    Rincón-León, Héctor
    Smolskis, Mary
    Mateja,Allyson
    Hunsberger, Sally
    Beigel, John H
    Ruiz-Palacios, Guillermo

  2. Author Address

    Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cos 237;o Villegas, Mexico City, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico. Electronic address: joazu@yahoo.com., Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cos 237;o Villegas, Mexico City, Mexico; Escuela Nacional de Ciencias Biol 243;gicas, Instituto Polit 233;cnico Nacional, Mexico City, Mexico., Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cos 237;o Villegas, Mexico City, Mexico., Instituto de Investigaciones M 233;dico-Biol 243;gicas, Universidad Veracruzana, Veracruz, Mexico., Department for Immunological Investigations, Instituto de Diagn 243;stico y Referencia Epidemiol 243;gica, Mexico City, Mexico., FES Iztacala, Universidad Nacional Aut 243;noma de M 233;xico, Mexico City, Mexico., Departamento de Infectolog 237;a, Instituto Nacional de Ciencias M 233;dicas y Nutrici 243;n Salvador Zubir 225;n, Mexico City, Mexico; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, USA., Departamento de Infectolog 237;a, Instituto Nacional de Ciencias M 233;dicas y Nutrici 243;n Salvador Zubir 225;n, Mexico City, Mexico., Hospital Regional de Alta Especialidad Ciudad Salud, Tapachula, Chiapas, Mexico., Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Tapachula, Chiapas, Mexico., Instituto Mexicano del Seguro Social, Tapachula, Chiapas, Mexico., Leidos Biomedical Research, Frederick, Maryland, USA., Biostatistics Research Branch (BRB), National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.,
    1. Year: 2020
    2. Date: MAY
    3. Epub Date: 2020 02 17
  2. Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
    1. 94
    2. Pages: 4-11
  4. Type of Article: Article
  5. ISSN: 1201-9712
  1. Abstract:

    Objectives: To describe the kinetics of circulating cytokines and chemokines in humans with ZIKAV infection. Methods: Serum levels of different immune mediators in patients with ZIKAV infection were measured at distinct stages of the disease, as well as in culture supernatants from human monocytes infected with a clinical ZIKAV isolate. We also looked for clinical features associated with specific immune signatures among symptomatic patients. Results: We evaluated 23 ZIKAV-infected patients. Their mean age was 32 +/- 8.3 years and 65% were female. ZIKAV patients showed elevated IL-9, IL-17A, and CXCL10 levels at acute stages of the disease. At day 28, levels of CCL4 and CCL5 were increased, whereas IL-1RA, CXCL8 and CCL2 were decreased. At baseline, IL-7 was increased among patients with headache, whereas CCL2, and CCL3 were decreased in patients with bleeding and rash, respectively. Our clinical ZIKAV isolate induced a broad immune response in monocytes that did not resemble the signature observed in ZIKAV patients. Conclusions: We showed a unique immune signature in our cohort of ZIKAV-infected patients. Our study may provide valuable evidence helpful to identify immune correlates of protection against ZIKAV. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.ijid.2020.02.014
  3. PMID: 32081772
  4. View record in Web of Science®
  5. WOS: 000533643700002
  6. PII : S1201-9712(20)30072-2

Library Notes

  1. Fiscal Year: FY2019-2020
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