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Mapping of Diabetes Susceptibility Loci in a Domestic Cat Breed with an Unusually High Incidence of Diabetes Mellitus

  1. Author:
    Balmer, Lois [ORCID]
    O'Leary, Caroline Ann
    Menotti-Raymond, Marilyn
    David,Victor
    O'Brien, Stephen
    Penglis, Belinda
    Hendrickson, Sher
    Reeves-Johnson, Mia
    Gottlieb, Susan
    Fleeman, Linda
    Vankan, Dianne [ORCID]
    Rand, Jacquie
    Morahan, Grant

  2. Author Address

    Centre for Diabetes Research, Harry Perkins Institute for Medical Research, University of Western Australia, Nedlands 6009, Australia., School of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth 6027, Australia., School of Veterinary Science, the University of Queensland, Gottan 4343, Australia., Laboratory of Genomic Diversity, Center for Cancer Research (FNLCR), Frederick, MD 21702, USA., Laboratory of Basic Research, Center for Cancer Research (FNLCR), National Cancer Institute, Frederick, MD 21702, USA., Laboratory of Genomics Diversity, Center for Computer Technologies, ITMO University, 197101 St. Petersburg, Russia., Guy Harvey Oceanographic Center, Halmos College of Arts and Sciences, Nova Southeastern University, Ft Lauderdale, FL 33004, USA., IDEXX Laboratories, East Brisbane 4169, Australia., Department of Biology, Shepherd University, Shepherdstown, WV 25443, USA., Animal Diabetes Australia, Melbourne 3155, Australia., American College of Veterinary Internal Medicine, University of Zurich, 8006 Zurich, Switzerland.,
    1. Year: 2020
    2. Date: Nov 19
    3. Epub Date: 2020 11 19
  2. Journal: Genes
    1. 11
    2. 11
    3. Pages: 1369
  4. Type of Article: Article
  5. Article Number: 1369
  6. ISSN: 2073-4425
  1. Abstract:

    Genetic variants that are associated with susceptibility to type 2 diabetes (T2D) are important for identification of individuals at risk and can provide insights into the molecular basis of disease. Analysis of T2D in domestic animals provides both the opportunity to improve veterinary management and breeding programs as well as to identify novel T2D risk genes. Australian-bred Burmese (ABB) cats have a 4-fold increased incidence of type 2 diabetes (T2D) compared to Burmese cats bred in the United States. This is likely attributable to a genetic founder effect. We investigated this by performing a genome-wide association scan on ABB cats. Four SNPs were associated with the ABB T2D phenotype with p values <0.005. All exons and splice junctions of candidate genes near significant single-nucleotide polymorphisms (SNPs) were sequenced, including the genes DGKG, IFG2BP2, SLC8A1, E2F6, ETV5, TRA2B and LIPH. Six candidate polymorphisms were followed up in a larger cohort of ABB cats with or without T2D and also in Burmese cats bred in America, which exhibit low T2D incidence. The original SNPs were confirmed in this cohort as associated with the T2D phenotype, although no novel coding SNPs in any of the seven candidate genes showed association with T2D. The identification of genetic markers associated with T2D susceptibility in ABB cats will enable preventative health strategies and guide breeding programs to reduce the prevalence of T2D in these cats.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/genes11111369
  3. PMID: 33228033
  4. View record in Web of Science®
  5. WOS: 000593399600001
  6. PII : genes11111369

Library Notes

  1. Fiscal Year: FY2020-2021
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