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The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer

  1. Author:
    Tian, Cuimeng
    Chen,Keqiang
    Gong, Wanghua
    Yoshimura, Teizo
    Huang, Jiaqiang
    Wang,Jiming [ORCID]

  2. Author Address

    Department of Radiation Oncology, Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital, Capital Medical University, Beijing, China., Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA., Basic Research Program, Leidos Biomedical Research, Inc., Frederick, MD, USA., Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan., Laboratory of Cancer Basic Research, Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital, Capital Medical University, Beijing, China.,
    1. Year: 2020
    2. Date: Jan-Dec
  2. Journal: Technology in cancer research & treatment
    1. 19
    2. Pages: pii: 1533033820973280
  4. Type of Article: Article
  5. Article Number: 1533033820973280
  6. ISSN: 1533-0346
  1. Abstract:

    Chronic inflammation is a causative factor of many cancers, although it originally acts as a protective host response to the loss of tissue homeostasis. Many inflammatory conditions predispose susceptible cells, most of which are of epithelial origin, to neoplastic transformation. There is a close correlation between digestive tract (DT) cancer and chronic inflammation, such as esophageal adenocarcinoma associated with Barrett 39;s esophagus, helicobacter pylori infection as the cause of stomach cancer, hepatitis leading to liver cirrhosis and subsequent cancer, and colon cancer linking to inflammatory bowel diseases and schistosomiasis. A prominent feature of malignant transformation of DT tract epithelial cells is their adoption of somatic gene mutations resulting in abnormal expression of proteins that endow the cells with unlimited proliferation as well as increased motility and invasive capabilities. Many of these events are mediated by Gi-protein coupled chemoattractant receptors (GPCRs) including formyl peptide receptors (FPRs in human, Fprs in mice). In this article, we review the current understanding of FPRs (Fprs) and their function in DT cancer types as well as their potential as therapeutic targets.

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External Sources

  1. View Full Text
  2. DOI: 10.1177/1533033820973280
  3. PMID: 33251986
  4. View record in Web of Science®
  5. WOS: 000596089400001

Library Notes

  1. Fiscal Year: FY2020-2021
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