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Rapid response to emerging biomedical challenges and threats

  1. Author:
    Grabowski, Marek [ORCID]
    Macnar, Joanna M [ORCID]
    Cymborowski, Marcin
    Cooper, David R [ORCID]
    Shabalin, Ivan G [ORCID]
    Gilski, Miroslaw [ORCID]
    Brzezinski, Dariusz [ORCID]
    Kowiel, Marcin [ORCID]
    Dauter,Zbigniew [ORCID]
    Rupp, Bernhard [ORCID]
    Wlodawer,Alexander [ORCID]
    Jaskolski, Mariusz [ORCID]
    Minor, Wladek [ORCID]

  2. Author Address

    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA., College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Warsaw, Poland., Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Warsaw, Poland., Department of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Poznan, Poland., Center for Biocrystallographic Research, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland., Institute of Computing Science, Poznan University of Technology, Poznan, Poland., Center for Structural Biology, National Cancer Institute, Frederick, Maryland, USA., k.-k Hofkristallamt, San Diego, California, USA., Institute of Genetic Epidemiology, Medical University Innsbruck, Innsbruck, Austria.,
    1. Year: 2021
    2. Date: May 01
    3. Epub Date: 2021 03 26
  2. Journal: IUCrJ
    1. 8
    2. Pt 3
    3. Pages: 395-407
  4. Type of Article: Article
  5. ISSN: 2052-2525
  1. Abstract:

    As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within less than a year. The avalanche of new structural data has given rise to multiple resources dedicated to assessing the correctness and quality of structural data and models. Here, an approach to evaluate the massive amounts of such data using the resource https://covid19.bioreproducibility.org is described, which offers a template that could be used in large-scale initiatives undertaken in response to future biomedical crises. Broader use of the described methodology could considerably curtail information noise and significantly improve the reproducibility of biomedical research. © Marek Grabowski et al. 2021.

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External Sources

  1. View Full Text
  2. DOI: 10.1107/S2052252521003018
  3. PMID: 33953926
  4. PMCID: PMC8086160
  5. View record in Web of Science®
  6. WOS: 000646827800009
  7. PII : S2052252521003018

Library Notes

  1. Fiscal Year: FY2020-2021
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