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Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma

  1. Author:
    Chen, Yulong
    Yang, Xunjun
    Chen, Yao
    Chen, Guorong
    Winkler,Cheryl
    An,Ping
    Lyu, Jianxin

  2. Author Address

    Wenzhou Med Univ, Key Lab Lab Med, Zhejiang Prov Key Lab Med Genet, Minist Educ, Wenzhou, Zhejiang, Peoples R China.Wenzhou Med Univ, Affiliated Hosp 2, Dept Lab Med, Wenzhou, Zhejiang, Peoples R China.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou, Zhejiang, Peoples R China.Frederick Natl Lab Canc Res, Basic Sci Program, Frederick, MD 21701 USA.Hangzhou Med Coll, Affiliated Hosp, Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China.
    1. Year: 2021
    2. Date: May 26
    3. Epub Date: 2021 05 26
  2. Journal: BMC cancer
  3. BMC,
    1. 21
    2. 1
  5. Type of Article: Article
  6. Article Number: 615
  7. ISSN: 1471-2407
  1. Abstract:

    BackgroundHepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains a major public health problem and its pathogenesis remains unresolved. A recent proteomics study discovered a lipid enzyme Sterol O-acyltransferase (SOAT1) involvement in the progression of HCC. We aimed to explore the association between SOAT1 genetic variation and HCC.MethodsWe genotyped three exonic SOAT1 variants (rs10753191, V323V; rs3753526, L475L; rs13306731, Q526R) tagging most variations in the gene, in 221 HCC patients and 229 healthy individuals, to assess the impact of SOAT1 gene variation on risk of HCC occurrence. We further conducted immunohistochemistry to compare SOAT1 protein expression levels in 42 paired tumor and adjacent non-tumor tissues.ResultsWe found that rs10753191 (Odds ratio (OR)=0.58, P=0.04) and a haplotype TGA (OR=0.40, P=0.01) were associated with reduced HCC risk after adjusting for lipid levels. In the immunohistochemistry experiment, we found that the protein expression of SOAT1 was significantly increased in the tumor compared with adjacent tissue (P< 0.001).ConclusionThis study revealed for the first time SOAT1 genetic variation that associates with host susceptibility to HCC occurrence. Our results suggest a role of SOAT1 in the HCC development, which warrants further elucidation.

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External Sources

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  2. DOI: 10.1186/s12885-021-08245-1
  3. PMID: 34039309
  4. PMCID: PMC8152151
  5. View record in Web of Science®
  6. WOS: 000658426700003

Library Notes

  1. Fiscal Year: FY2020-2021
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