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A Retrospective Survey among SARS-CoV-1 Infected Healthcare Workers after Three Years Post-Infection

  1. Author:
    Huang,Szu-Wei
    Urbina, Aspiro Nayim
    Chen, Yi-Ming Arthur
    Wang, Sheng-Fan

  2. Author Address

    NCI, Model Dev Sect, Basic Res Lab, Ctr Canc Res, Frederick, MD 21702 USA.Kaohsiung Med Univ, Ctr Trop Med & Infect Dis, Kaohsiung 80708, Taiwan.Fu Jen Catholic Univ, Grad Inst Biomed & Pharmaceut Sci, New Taipei 242062, Taiwan.Natl Hlth Res Inst, Inst Infect Dis & Vaccinol, Zhunan 35053, Miaoli County, Taiwan.Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung 80708, Taiwan.Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 80708, Taiwan.
    1. Year: 2021
    2. Date: Aug 25
  2. Journal: Pathogens
  3. MDPI
    1. 10
    2. 9
  5. Type of Article: Article
  6. Article Number: ARTN 1078
  7. ISSN: 2076-0817
  1. Abstract:

    Healthcare workers (HCWs) are on the frontline fighting several infectious diseases including SARS-CoV-1 and COVID-19. Coronavirus neutralizing antibodies (nAbs) were recently reported to last for a certain period. The factors affecting nAbs' existence remain unclear. Here, we retrospectively analyzed the factors correlating with nAbs' from SARS-CoV-1 long-term convalescence HCWs in Taiwan. One hundred and thirty SARS-CoV-1 convalescent patients were recruited between August 2006 and March 2007. Blood samples were collected to determine the anti-nucleocapsid (N) and anti-spike (S) antibodies' existence status and neutralization ability. Neutralization ability was measured using SARS-CoV-1 pseudotyped viruses. Statistical analysis of factors associated with anti-SARS-CoV-1 antibodies' existence status was determined using SAS software. 46.2% SARS-CoV-1 convalescent patients presented anti-N antibody after three years post-infection. Among sixty participants, ten participants co-presented anti-S antibodies. Eight participants with anti-S antibody displayed neutralization ability to SARS-CoV-1. The gender, age, and disease severity of participants did not affect the anti-N antibody existence status, whereas the anti-S antibody is significantly reduced in participants with old age (>50 years, p = 0.0434) after three years post SARS-CoV-1 infection. This study suggests that age is an important factor correlated with the duration of SARS-CoV-1 protective antibody existence status.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/pathogens10091078
  3. PMID: 34578111
  4. PMCID: PMC8465910
  5. View record in Web of Science®
  6. WOS: 000701753500001

Library Notes

  1. Fiscal Year: FY2020-2021
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