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Bacterial lipoproteins in sepsis

  1. Author:
    Kandahalli Venkataranga Nayaka,Abhilasha
    Marathe, Gopal Kedihithlu

  2. Author Address

    Univ Mysore, Dept Studies Biochem, Mysuru 570006, Karnataka, India.NCI, Canc & Dev Biol Lab, Frederick, MD 21702 USA.Univ Mysore, Dept Studies Mol Biol, Mysuru 570006, Karnataka, India.
    1. Year: 2021
    2. Date: Sep
    3. Epub Date: 2021 08 20
  2. Journal: IMMUNOBIOLOGY
  3. ELSEVIER GMBH,
    1. 226
    2. 5
  5. Type of Article: Review
  6. Article Number: 152128
  7. ISSN: 0171-2985
  1. Abstract:

    Bacterial lipoproteins are membrane proteins derived from both gram-negative and gram-positive bacteria. They seem to have diverse functions not only on bacterial growth, but also play an important role in host's virulence. Bacterial lipoproteins exert their action on host immune cells via TLR2/1 or TLR2/6. Therefore, bacterial lipoproteins also need to be considered while addressing bacterial pathogenicity besides classical bacterial endotoxin like LPS and other microbial associated molecular patterns such as LTA, and peptidoglycans. In this mini-review, we provide an overview of general bacterial lipoprotein biosynthesis and the need to understand the lipoprotein-mediated pathogenicity in diseases like sepsis.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.imbio.2021.152128
  3. PMID: 34488139
  4. View record in Web of Science®
  5. WOS: 000701357400006

Library Notes

  1. Fiscal Year: FY2021-2022
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