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Monitoring PSMA Responses to ADT in Prostate Cancer Patient-Derived Xenograft Mouse Models Using [F-18]DCFPyL PET Imaging

  1. Author:
    Roy, Jyoti
    White, Margaret E.
    Basuli, Falguni
    Opina, Ana Christina L.
    Wong, Karen
    Riba, Morgan
    Ton, Anita T.
    Zhang, Xiang
    Jansson, Keith H.
    Edmondson,Elijah
    Butcher,Donna
    Lin, Frank I.
    Choyke, Peter L.
    Kelly, Kathleen
    Jagoda, Elaine M.

  2. Author Address

    NCI, Mol Imaging Program, NIH, Ctr Canc Res, Bldg 10,Room B3B406, Bethesda, MD 20892 USA.NCI, Lab Genitourinary Canc Pathogenesis, NIH, Bethesda, MD 20892 USA.NHLBI, Chem & Synth Ctr, NIH, Rockville, MD USA.NCI, Pathol Histotechnol Lab, Leidos Inc, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.
    1. Year: 2021
    2. Date: Oct
    3. Epub Date: 2021 Apr 23
  2. Journal: Molecular Imaging and Biology
  3. Springer
    1. 23
    2. 5
    3. Pages: 745-755
  5. Type of Article: Article
  6. ISSN: 1536-1632
  1. Abstract:

    Purpose: PSMA overexpression has been associated with aggressive prostate cancer (PCa). However, PSMA PET imaging has revealed highly variable changes in PSMA expression in response to ADT treatment ranging from increases to moderate decreases. To better understand these PSMA responses and potential relationship to progressive PCa, the PET imaging agent, [F-18]DCFPyL, was used to assess changes in PSMA expression in response to ADT using genomically characterized LuCaP patient-derived xenograft mouse models (LuCaP-PDXs) which were found to be sensitive to ADT (LuCaP73 and LuCaP136;CS) or resistant (LuCaP167;CR).

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External Sources

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  2. DOI: 10.1007/s11307-021-01605-0
  3. PMID: 33891265
  4. View record in Web of Science®
  5. WOS: 000642837300001

Library Notes

  1. Fiscal Year: FY2020-2021
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