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Actin-binding cellular proteins inside human immunodeficiency virus type 1

  1. Author:
    Ott, D. E.
    Coren, L. V.
    Johnson, D. G.
    Kane, B. P.
    Sowder, R. C.
    Kim, Y. D.
    Fisher, R. J.
    Zhou, X. Z.
    Lu, K. P.
    Henderson, L. E.

  2. Author Address

    Ott DE NCI, Frederick Canc Res & Dev Ctr, SAIC, AIDS Vaccine Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, SAIC, AIDS Vaccine Program Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, SAIC, Prot Chem Lab Frederick, MD 21702 USA Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med,Dept Med, Div Hematol & Oncol,Canc Biol Program Boston, MA 02215 USA
    1. Year: 2000
  2. Journal: Virology
    1. 266
    2. 1
    3. Pages: 42-51
  4. Type of Article: Article
  1. Abstract:

    Host proteins are incorporated both on and inside human immunodeficiency virus type 1 (HIV-1) virions. To identify cellular proteins inside HIV-1, virion preparations were treated by a protease-digestion technique that removes external host proteins, allowing for the study of the proteins inside the virus. Treated HIV-1 preparations were analyzed by immunoblot, high-pressure liquid chromatography, and protein sequence analyses. These analyses identified several cellular proteins inside HIV-1: elongation factor 1 alpha, glyceraldehyde-3-phosphate dehydrogenase, HS-1, phosphatidylethanolamine-binding protein, Pin1, Lck, Nm23-H1, and the C-terminal tail of CD43. Several of these proteins were found as fragments of their full-sized proteins that appear to be generated by our protease treatment of the virions, the HIV-1 protease, or a cellular protease. Recent advances in cell biology and biochemistry have identified some of these proteins as actin-binding proteins. These results support the hypothesis that actin filaments are incorporated into the virion and may provide additional clues for the understanding of the interaction between viral and cellular proteins during assembly and budding. (C) 2000 Academic Press. [References: 58]

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