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Chromium mapping in male mice reproductive glands exposed to CrCl3 using proton and X-ray synchrotron radiation microbeams

  1. Author:
    Ortega, R.
    Deves, G.
    Bonnin-Mosbah, M.
    Salome, M.
    Susini, J.
    Anderson, L. M.
    Kasprzak, K. S.

  2. Author Address

    Univ Bordeaux 1, CNRS UMR 5084, LCNAB, BP 120 Haut Vigneau, F- 33175 Gradignan, France. Univ Bordeaux 1, CNRS UMR 5084, LCNAB, F-33175 Gradignan, France. CE Saclay, CEA, CNRS, LPS, F-91191 Gif Sur Yvette, France. ESRF, F-38043 Grenoble, France. NCI, Comparat Carcinogenesis Lab, Frederick, MD 21702 USA. Ortega R Univ Bordeaux 1, CNRS UMR 5084, LCNAB, BP 120 Haut Vigneau, F-33175 Gradignan, France.
    1. Year: 2001
  2. Journal: Nuclear Instruments & Methods in Physics Research Section B- Beam Interactions with Materials and Atoms
    1. 181
    2. Pages: 485-488
  4. Type of Article: Article
  1. Abstract:

    Preconception exposure to certain chemicals may increase risk of tumors in offspring, especially with regard to occupational metals such as chromium. However, the mechanism of chromium trans-generation carcinogenicity remains unknown. Using scanning proton X-ray microanalysis we have been able to detect chromium in testicular tissue sections from mice treated by intraperitoneal injection of I mmol/kg CrCl3. Chromium concentration was about 5 mug/g dry mass in average, but higher concentrations were found within the limiting membrane of the testes, the tunica albuginea. In addition, synchrotron radiation X-ray fluorescence measurements, with microscopic resolution, clearly demonstrated the presence of chromium in the tunica albuginea but also within isolated cells from the interstitial connective tissue. (C) 2001 Elsevier Science B.V. All rights reserved.

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