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Control of chromatin accessibility for V(D)J recombination by interleukin-7

  1. Author:
    Huang, J. Q.
    Muegge, K.

  2. Author Address

    NCI, SAIC, FCRDC, Mol Immunoregulat Lab, Bldg 560, Rm 31-45, Frederick, MD 21702 USA. NCI, SAIC, FCRDC, Mol Immunoregulat Lab, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Journal of Leukocyte Biology
    1. 69
    2. 6
    3. Pages: 907-911
  4. Type of Article: Review
  1. Abstract:

    IL-7 is a key factor for lymphoid development, and it contributes to V(D)J recombination at multiple loci in immune- receptor genes, IL-7 signal transduction, involving gamma (c) and Jak3, is required for successful recombination at the TCR- gamma locus, IL-7 signaling controls the initiation phase of V(D)J recombination by controlling access of the V(D)J recombinase to the locus. in the absence of IL-7, the TCR-gamma locus is methylated and packaged in a repressed form of chromatin consisting of hypoacetylated histones, IL-7 signaling likely increases the acetylation state of the nucleosomal core histones resulting in an "open" form of chromatin. This opening leads to a higher accessibility for the transcription machinery and increased accessibility of the Rag heterodimer that performs the cleavage of DNA.

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