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Testing of new agents in childhood cancer preclinical models: Meeting summary

  1. Author:
    Houghton, P. J.
    Adamson, P. C.
    Blaney, S.
    Fine, H. A.
    Gorlick, R.
    Haber, M.
    Helman, L.
    Hirschfeld, D.
    Hollingshead, M. G.
    Israel, M. A.
    Lock, R. B.
    Maris, J. M.
    Merlino, G.
    Patterson, W.
    Reynolds, C. P.
    Shannon, K.
    Yu, A.
    Yu, J.
    Smith, M. A.

  2. Author Address

    NCI, Canc Therapy Evaluat Program, Pediat Sect, 6130 Execut Blvd,Room 7025, Bethesda, MD 20892 USA St Jude Childrens Hosp, Memphis, TN 38101 USA Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA Texas Childrens Canc Ctr, Houston, TX 77024 USA Neurol Oncol Branch, Bethesda, MD 20892 USA Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA Univ New S Wales, Childrens Canc Inst Australia Med Res, Kensington, NSW 2033, Australia Sydney Childrens Hosp, Childrens Canc Inst Australia Med Res, Randwick, NSW, Australia NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA US FDA, Rockville, MD 20852 USA NCI, Biol Testing Branch, Frederick, MD 21702 USA Dartmouth Coll Sch Med, Norris Cotton Canc Ctr, Lebanon, NH 03756 USA NCI, Mol Genet Sect, Bethesda, MD 20892 USA NCI, Technol Transfer Branch, Bethesda, MD 20892 USA Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA Univ Calif San Diego, Med Ctr, San Diego, CA 92103 USA Scripps Clin & Res Inst, La Jolla, CA 92037 USA NCI, Canc Therapy Evaluat Program, Pediat Sect, Bethesda, MD 20892 USA Smith MA NCI, Canc Therapy Evaluat Program, Pediat Sect, 6130 Execut Blvd,Room 7025, Bethesda, MD 20892 USA
    1. Year: 2002
  2. Journal: Clinical Cancer Research
    1. 8
    2. 12
    3. Pages: 3646-3657
  4. Type of Article: Review
  1. Abstract:

    A workshop on pediatric preclinical testing, sponsored by the National Cancer Institute and the Children's Oncology Group Phase 1 Consortium, was held on June 26-27, 2001 in Bethesda, Maryland. Drs. Peter Adamson, Peter Houghton, and Malcolm Smith organized and hosted the meeting. There were 20 participants from 12 institutions. The primary objectives of the workshop included: (a) development of a working inventory of available preclinical models (including human tumor xenografts in immunodeficient mice, transgenic and syngeneic tumors, and selected in vitro models), with a basic understanding of the strengths and weaknesses of each as possible components of a preclinical testing program; (b) identification of the key scientific issues related to establishment of a program for preclinical testing of new agents for their applicability to childhood cancers; and (c) identification of the key infrastructure requirements for a program for preclinical testing of new agents for their applicability to childhood cancers. This report is a synthesis of the workshop's presentations and discussions.

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