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p73: Friend or foe in tumorigenesis

  1. Author:
    Melino, G.
    De Laurenzi, V.
    Vousden, K. H.

  2. Author Address

    Univ Roma Tor Vergata, Biochem Lab, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy Univ Roma Tor Vergata, Biochem Lab, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy NCI, Regulat Cell Growth Lab, Frederick, MD 21702 USA Melino G Univ Roma Tor Vergata, Biochem Lab, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy
    1. Year: 2002
  2. Journal: Nature Reviews Cancer
    1. 2
    2. 8
    3. Pages: 605-615
  4. Type of Article: Review
  1. Abstract:

    As p53 and its homologue p73 have significant sequence and functional similarities, p73 might also be expected to act as a tumour suppressor However, p73 is activated after DNA damage in a way that is distinct from that of p53. The existence of DeltaNp73 - an isoform of p73 that is encoded by a distinct promoter and that lacks the transactivation domain - further complicates matters. It seems to function as an oncogene by inhibiting both p73- and p53-induced apoptosis. So how can these opposing functions be reconciled in human tumours?.

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