Skip NavigationSkip to Content
Return Return to Search Results

CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection

  1. Author:
    Verthelyi, D.
    Gursel, M.
    Kenney, R. T.
    Lifson, J. D.
    Liu, S. Y.
    Mican, J.
    Klinman, D. M.

  2. Author Address

    Bldg 29A,Room 3B19,8800 Rockville Pike, Bethesda, MD 20892 USA US FDA, Ctr Biol Evaluat & Res, Sect Retroviral Immunol, Bethesda, MD 20892 USA US FDA, Ctr Biol Evaluat & Res, Div Bacterial Parasit & Allergen Prod, Bethesda, MD 20892 USA NCI, AIDS Vaccine Program, Sci Applicat Int Corp, Frederick, MD 21702 USA NIAID, Immunoregulat Lab, Natl Inst Hlth, Bethesda, MD 20892 USA Verthelyi D Bldg 29A,Room 3B19,8800 Rockville Pike, Bethesda, MD 20892 USA
    1. Year: 2003
  2. Journal: Journal of Immunology
    1. 170
    2. 9
    3. Pages: 4717-4723
  4. Type of Article: Article
  1. Abstract:

    Oligodeoxynucleotides containing CpG motifs (CpG ODNs) mimic microbial DNA and activate effectors of the innate immune response, which limits the spread of pathogens and promotes an adaptive immune response. CpG ODNs have been shown to protect mice from infection with intracellular pathogens. Unfortunately, CpG motifs that optimally stimulate humans are only weakly active in mice, mandating the use of nonhuman primates to monitor the activity and safety of "human" CpG ODNs in vivo. This study demonstrates that CpG ODN treatment of rhesus macaques significantly reduces the severity of the lesions caused by a challenge with Leishmania. Leishmania superinfection is common in immunocompromised hosts, particularly those infected with HIV. This study shows that PBMCs from HIV-infected subjects respond to stimulation with CpG ODNs. To determine whether CpG ODNs can protect retrovirus- infected primates, SIV-infected macaques were treated with CpG ODNs and then challenged with Leishmania. Both lesion size and parasite load were significantly reduced in the CpG-treated animals. These findings support the clinical development of CpG ODNs as immunoprotective agents in normal and HIV-infected patients.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel